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Meta-Analysis
. 2022 Nov 19;11(1):247.
doi: 10.1186/s13643-022-02123-y.

Prognostic significance of systemic immune-inflammation index in patients with nasopharyngeal carcinoma: a meta-analysis

Zesheng Zeng  1 , Shengen Xu  1 , Dingting Wang  1 , Gang Qin  2
Affiliations
Meta-Analysis

Prognostic significance of systemic immune-inflammation index in patients with nasopharyngeal carcinoma: a meta-analysis

Zesheng Zeng et al. Syst Rev. .

Abstract

Background: Previous studies have investigated the prognostic value of the systemic immune-inflammation index (SII) in nasopharyngeal carcinoma (NPC). However, the results have been inconsistent. Therefore, this study aims to investigate the prognostic significance of SII in NPC through a meta-analysis.

Methods: The PubMed, Web of Science, Embase, and Cochrane Library databases were thoroughly searched. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to evaluate the prognostic value of the SII for survival outcomes.

Results: A total of six studies comprising 2169 patients were included in the meta-analysis. Pooled analyses indicated that a high SII was significantly associated with worse overall survival (OS) (HR = 1.69, 95% CI = 1.36-2.09, P < 0.001) and progression-free survival (PFS) (HR = 1.60, 95% CI = 1.29-1.98, P < 0.001) in patients with NPC. Subgroup analysis showed that SII was a significant prognostic marker for PFS but not for OS in NPC.

Conclusion: Our meta-analysis demonstrated that a high SII could be an efficient prognostic indicator of OS and PFS in NPC. In our opinion, SII could be used to predict long-term and short-term outcomes in patients with NPC. Furthermore, we suggest that SII be applied to help individual patients with NPC assess the prognostic risk.

Systematic review registration: PROSPERO CRD42022321570.

Keywords: Meta-analysis; Prognosis,·Nasopharyngeal carcinoma; Systemic immune-inflammation index.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of study selection
Fig. 2
Fig. 2
Forest plots reflecting the association between SII and OS (a)/PFS (b) in NPC. SII, systemic immune-inflammation index; PFS, progression-free survival
See this image and copyright information in PMC

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