A review on the role of PCGEM1 lncRNA in cancer

Abstract

PCGEM1 Prostate-Specific Transcript is an lncRNA participating in the carcinogenesis process in different tissues. The gene coding this lncRNA is located on chr2:192,749,008-192,783,952 (GRCh38/hg38), plus strand and has 34,945 bases. In addition to prostate cancer, it has been shown to influence progression of cervical, endometrial, gastric, ovarian, hepatocellular and renal cancers. Functionally, PCGEM1 regulates activity of a number of molecular axes, namely miR-642a-5p/LGMN, miR-182/FBXW11, miR-129-5p/STAT3, miR-129-5p/P4HA2, miR-433-3p/FGF2, miR-539-5p/CDK6, miR-129-5p/ETV1, miR-433-3p/WTAP, miR-590-3p/SOX11 and miR-506-3p/TRIAP1. Moreover, it has a regulatory effect on RhoA, NF-κB and β-catenin/TCF signaling pathways. We have designed this literature search to collect all relevant data about the function of PCGEM1 in the carcinogenesis.

Keywords: Cancer; Expression; LncRNA; PCGEM1; Prostate cancer.