De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019
- PMID: 36403401
- PMCID: PMC9628129
- DOI: 10.1016/j.jiph.2022.10.025
De novo natural anti-M alloantibody emergence in severe Coronavirus Disease 2019
Abstract
The immune response is a key player in the course of SARS-CoV-2 infection, and is often seriously dysfunctional in severe Coronavirus Disease 2019. The hyperinflammatory status has been described to be accompanied by the appearance of autoantibodies. In a lethal COVID-19 infection, we observed the emergence of a de novo natural alloantibody which targeted the M antigen from the MNS blood group on red blood cells (RBC) without evidence of any cross-reaction with SARS-CoV-2 antigens. This IgM lambda alloantibody was unmutated and unswitched. Here, we describe for the first time the emergence of a bystander de novo natural alloantibody against RBCs in a severe COVID-19 patient, highlighting the extra-follicular humoral response reported in these cases.
Keywords: Alloantibody; COVID-19; M-antigen; Transfusion.
Copyright © 2022. Published by Elsevier Ltd.
Conflict of interest statement
Conflict of interest Authors have no competing interest to disclose.
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References
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- Woodruff M.C., Ramonell R.P., Saini A.S., Haddad N.S., Anam F.A., Rudolph M.E., et al. Relaxed peripheral tolerance drives broad de novo autoreactivity in severe COVID-19. medRxiv. 2021;2020.10.21.20216192. https://doi.org/10.1101/2020.10.21.20216192.
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