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. 2022 Dec:65:102978.
doi: 10.1016/j.scr.2022.102978. Epub 2022 Nov 15.

Generation of a new human induced pluripotent stem cell (hiPSC) line from a South Asian Indian with a MYBPC3Δ25bp variant

Prasanth Chimata  1 , Deepak K Kashyap  2 , Thiagarajan Sairam  3 , Akshayaa Ganesh  4 , Kumarasamy Thangaraj  5 , Meera Purushottam  4 , Biju Viswanath  4 , Sanjeev Jain  4 , Perundurai S Dhandapany  6
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Free article

Generation of a new human induced pluripotent stem cell (hiPSC) line from a South Asian Indian with a MYBPC3Δ25bp variant

Prasanth Chimata et al. Stem Cell Res. 2022 Dec.
Free article

Abstract

Myosin binding protein C3 (MYBPC3) is a thick filament contractile protein that interacts with myosin, titin and actin and regulates cardiac muscle contraction. Genetic variations in the MYBPC3 gene are known causal factors for cardiomyopathy and heart failure. Previously, we identified a recurrent MYBPC3 deletion (25 base pairs) among South Asians associated with cardiomyopathy and heart failure. Here, we generated an induced pluripotent stem cell (iPSC) line using peripheral blood mononuclear cells (PBMC) from an Indian harboring MYBPC3 deletion. This iPSC line displayed embryonic stem cell morphology, expressed pluripotency markers, differentiated into three germ layers and exhibited normal karyotype.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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