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. 2023 Apr;11(4):1123-1133.e11.
doi: 10.1016/j.jaip.2022.10.048. Epub 2022 Nov 17.

Differences in Self-Reported Food Allergy and Food-Associated Anaphylaxis by Race and Ethnicity Among SAPPHIRE Cohort Participants

Shujie Xiao  1 , Neha Sahasrabudhe  1 , Mao Yang  1 , Donglei Hu  2 , Patrick Sleiman  3 , Samantha Hochstadt  1 , Whitney Cabral  1 , Frank Gilliland  4 , W James Gauderman  4 , Fernando Martinez  5 , Hakon Hakonarson  3 , Rajesh Kumar  6 , Esteban G Burchard  7 , L Keoki Williams  8
Affiliations

Differences in Self-Reported Food Allergy and Food-Associated Anaphylaxis by Race and Ethnicity Among SAPPHIRE Cohort Participants

Shujie Xiao et al. J Allergy Clin Immunol Pract. 2023 Apr.

Abstract

Background: Although food allergies are considered common, relatively little is known about disparities in food allergy by race in the United States.

Objective: To evaluate differences in reported food allergy and food-associated anaphylaxis among individuals enrolled in a longitudinal cohort study from metropolitan Detroit, Michigan.

Methods: Participants in the Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE) were asked about food allergies, including the inciting food and associated symptoms. Individuals were considered to have food-associated anaphylaxis if symptoms coincided with established clinical criteria. Logistic regression was used to assess whether race difference persisted after adjusting for and stratifying by potential confounders. African genetic ancestry was individually estimated among African American SAPPHIRE participants to assess whether ancestry was associated with food allergy.

Results: Within the SAPPHIRE cohort, African American participants were significantly more likely to report food allergy (26.1% vs 17%; P = 3.47 × 10-18) and have food-associated anaphylactic symptoms (12.7% vs 7%; P = 4.65 × 10-14) when compared with European American participants. Allergy to seafood accounted for the largest difference (13.1% vs 4.6%; P = 1.38 × 10-31). Differences in food allergy by race persisted after adjusting for potential confounders including asthma status. Among African American participants, the proportion of African ancestry was not associated with any outcome evaluated.

Conclusion: Compared with European Americans, African Americans appear to be at higher risk for developing food allergy and food-associated anaphylaxis, particularly with regard to seafood allergy. The lack of association with genetic ancestry suggests that socioenvironmental determinants may play a role in these disparities.

Keywords: Anaphylaxis; Food allergy; Genetic ancestry; Health status disparities.

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Conflict of interest statement

CONFLICT OF INTEREST STATEMENT

Dr. Martinez reports funding from the NHLBI, NIAID, NIEHS, and Office of the Director, NIH unrelated to the current work. Dr. Hakonarson reports funding from NHLBI and Children’s Hospital of Philadelphia related to the current work. Dr. Kumar reports NIH funding, consultant work for Regeneron, and honoraria from Indiana University and the Hospital for Sick Children (Toronto, Canada) unrelated to the current work. Dr. Burchard reports funding from the Sandler Family Foundation, the RWJF Amos Medical Faculty Development Program, and the NHLBI, the NIMHD, the NIGMS, NHGRI, and the NIEHS of the NIH related to the current work. Dr. Williams reports funding from the NIAID, the NHLBI, and the NIDDK related to the current work.

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