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Comment
. 2022 Dec;43(12):947-949.
doi: 10.1016/j.it.2022.10.007. Epub 2022 Nov 17.

Humans pIKK-up NLRP3 to skip NEK7

R K Subbarao Malireddi  1 , Thirumala-Devi Kanneganti  2
Affiliations
Comment

Humans pIKK-up NLRP3 to skip NEK7

R K Subbarao Malireddi et al. Trends Immunol. 2022 Dec.

Abstract

NLRP3 inflammasome regulation is essential for controlling cell death and inflammation. Mechanistic studies in murine cells suggest a two-step model of priming and activation with an indispensable role for NEK7. However, in a recent article in Immunity, Schmacke et al. report that, in humans, transcription-independent NLRP3 activation occurs by circumventing NEK7 via IKKβ.

Keywords: IKKβ; NEK7; NLRP3; TAK1; cell death; inflammasome.

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Conflict of interest statement

Declaration of interests T.-D.K. is a consultant for Pfizer.

Comment on

  • IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network.
    Schmacke NA, O'Duill F, Gaidt MM, Szymanska I, Kamper JM, Schmid-Burgk JL, Mädler SC, Mackens-Kiani T, Kozaki T, Chauhan D, Nagl D, Stafford CA, Harz H, Fröhlich AL, Pinci F, Ginhoux F, Beckmann R, Mann M, Leonhardt H, Hornung V. Schmacke NA, et al. Immunity. 2022 Dec 13;55(12):2271-2284.e7. doi: 10.1016/j.immuni.2022.10.021. Epub 2022 Nov 15. Immunity. 2022. PMID: 36384135 Free PMC article.

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