Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Nov 21;16(1):434.
doi: 10.1186/s13256-022-03654-7.

Osteolytic metatarsal osteomyelitis regenerated by combined treatment of artificial carbon dioxide foot bathing and povidone-iodine sugar ointment: a case report

Masakatsu Hihara  1 , Michika Fukui  2 , Toshihito Mitsui  2 , Natsuko Kakudo  2 , Atsuyuki Kuro  2
Affiliations
Case Reports

Osteolytic metatarsal osteomyelitis regenerated by combined treatment of artificial carbon dioxide foot bathing and povidone-iodine sugar ointment: a case report

Masakatsu Hihara et al. J Med Case Rep. .

Abstract

Background: In recent years, the number of patients with ischemic skin ulcers due to diabetes mellitus and arteriosclerosis obliterans are increasing. Accordingly, endovascular therapy, drugs, and various wound dressings have been developed and applied to diabetic foot ulcers, and negative-pressure wound therapy, which often requires expensive and burdensome procedures for medical personnel, has also become popular. So simple and minimal invasive home treatment by the patient or their caregiver is required.

Case presentation: The present patient (77 years old, male, Asian) had developed left sole ulcers with draining pus that were resistant to conventional treatment, and he suffered from gait disturbance. We report a case of metatarsal osteomyelitis in a patient with diabetes mellitus and arteriosclerosis obliterans, in whom artificial carbon dioxide foot bathing and povidone-iodine sugar ointment were used continuously to promote bone and joint regeneration, and skin ulcer healing.

Conclusions: A simple therapeutic intervention with artificial carbon dioxide foot bathing and povidone-iodine sugar ointment can improve not only ischemic skin ulcers, but also the bone and joint regeneration of ischemic limbs. This therapy can lead to a reduction in healthcare costs for a huge number of diabetic patients.

Keywords: Artificial carbon dioxide foot bathing; Bone and joint regeneration; Diabetic foot ulcers; Healthcare costs; Osteomyelitis; Povidone–iodine sugar ointment.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Pus discharge of the right plantar ulcer increased and the metatarsophalangeal joint of the second toe was destroyed and showed osteolytic changes. Yellow circle indicates osteolytic areas
Fig. 2
Fig. 2
One year and five months later, the wound was healing and radiographs showed the regeneration of a joint-like structure in the metatarsophalangeal joint of the second toe. Yellow circle indicates the regeneration of a joint-like structure
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Sancho-Mestre C, Vivas-Consuelo D, Alvis-Estrada L, Romero M, Uso-Talamantes R, Caballer-Tarazona V. Pharmaceutical cost and multimorbidity with type 2 diabetes mellitus using electronic health record data. Bmc Health Serv Res. 2016;17:16. - PMC - PubMed
    1. Hartmann BR, Bassenge E, Pittler M. Effect of carbon dioxide-enriched water and fresh water on the cutaneous microcirculation and oxygen tension in the skin of the foot. Angiology. 1997;48(4):337–343. doi: 10.1177/000331979704800406. - DOI - PubMed
    1. Hayashi H, Yamada S, Kumada Y, Matsuo H, Toriyama T, Kawahara H. Immersing feet in carbon dioxide-enriched water prevents expansion and formation of ischemic ulcers after surgical revascularization in diabetic patients with critical limb ischemia. Ann Vasc Dis. 2008;1(2):111–117. doi: 10.3400/avd.AVDoa08001. - DOI - PMC - PubMed
    1. Finzgar M, Melik Z, Cankar K. Effect of transcutaneous application of gaseous carbon dioxide on cutaneous microcirculation. Clin Hemorheol Microcirc. 2015;60(4):423–435. doi: 10.3233/CH-141898. - DOI - PubMed
    1. Yamazaki T, Ushikoshi-Nakayama R, Shakya S, Omagari D, Matsumoto N, Nukuzuma C, et al. The effects of bathing in neutral bicarbonate ion water. Sci Rep. 2021;11(1):21789. doi: 10.1038/s41598-021-01285-4. - DOI - PMC - PubMed

Publication types

LinkOut - more resources