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. 2023 Mar;58(3):973-979.
doi: 10.1002/ppul.26249. Epub 2022 Dec 5.

Mepolizumab: Therapeutic strategy for a pediatric patient with eosinophilic granulomatosis with polyangiitis

Lota Ozola  1   2 , Elīna Aleksejeva  1   2 , Diāna Stoldere  1   2 , Zane Dāvidsone  1   2 , Ruta Šantere  2 , Ineta Grantiņa  1   2 , Ieva Cīrule  1   2 , Alvils Krams  3   4
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Mepolizumab: Therapeutic strategy for a pediatric patient with eosinophilic granulomatosis with polyangiitis

Lota Ozola et al. Pediatr Pulmonol. 2023 Mar.

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA; formerly known as Churg-Strauss syndrome) is classified as an antineutrophil cytoplasmic antibody (ANCA)-associated small vessel vasculitis. It is a multisystem disorder and can affect every organ system. EGPA is a rare disease, with an estimated prevalence of 1/70,000-100,000 in Europe. As its onset usually occurs in adulthood, data from pediatric patients are limited. We present here a very rare practical EGPA clinical case involving a pediatric patient. Presently, data on mepolizumab usage in pediatric patients are limited, with only a few case reports published.

Keywords: mepolizumab in pediatrics; pediatric EGPA; small vessel vasculitis.

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