Research Progress of Robot Technology in In situ 3D Bioprinting

Xie Neng^{1

2}, Shi Guohong³, Shen Yuling^{3

4}, Xu Yuanjing³, Wang Hao⁵, Feng Haiyang⁶, Dai Kerong^{3

4}, Wang Jinwu^{3

4}, Cao Qixin¹

Affiliations

¹ Department of Biomedical Manufacturing and Engineering, School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, China.
² Center for Medical Devices and Cosmetics Evaluation and Inspection, Shanghai, China.
³ Department of Biomedical Instrument, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
⁴ Department of Orthopaedic Surgery, School of Medicine, Shanghai Ninth People's Hospital affiliated to Shanghai Jiao Tong University, Shanghai, China.
⁵ Department of Mechanical Engineering, School of Mechanical and Electrical Engineering, Henan University of Technology, Zhengzhou, China.
⁶ Department of Rehabilitation Medicine and Physical Therapy, School of Rehabilitation Medicine, Weifang Medical University, Weifang, China.

PMID: 36404787
PMCID: PMC9668572
DOI: 10.18063/ijb.v8i4.614

Review

Research Progress of Robot Technology in In situ 3D Bioprinting

Xie Neng et al. Int J Bioprint. 2022.

. 2022 Sep 13;8(4):614.

doi: 10.18063/ijb.v8i4.614. eCollection 2022.

Authors

Xie Neng^{1

2}, Shi Guohong³, Shen Yuling^{3

4}, Xu Yuanjing³, Wang Hao⁵, Feng Haiyang⁶, Dai Kerong^{3

4}, Wang Jinwu^{3

4}, Cao Qixin¹

Affiliations

¹ Department of Biomedical Manufacturing and Engineering, School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, China.
² Center for Medical Devices and Cosmetics Evaluation and Inspection, Shanghai, China.
³ Department of Biomedical Instrument, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
⁴ Department of Orthopaedic Surgery, School of Medicine, Shanghai Ninth People's Hospital affiliated to Shanghai Jiao Tong University, Shanghai, China.
⁵ Department of Mechanical Engineering, School of Mechanical and Electrical Engineering, Henan University of Technology, Zhengzhou, China.
⁶ Department of Rehabilitation Medicine and Physical Therapy, School of Rehabilitation Medicine, Weifang Medical University, Weifang, China.

PMID: 36404787
PMCID: PMC9668572
DOI: 10.18063/ijb.v8i4.614

Abstract

Three-dimensional (3D) bioprinting is an emerging research direction in bio-manufacturing, a landmark in the shift from traditional manufacturing to high-end manufacturing. It integrates manufacturing science, biomedicine, information technology, and material science. In situ bioprinting is a type of 3D bioprinting which aims to print tissues or organs directly on defective sites in the human body. Printed materials can grow and proliferate in the human body; therefore, the graft is similar to the target tissues or organs and could accurately match the defective site. This article mainly summarizes the current status of robotic applications in the medical field and reviews its research progress in in situ 3D bioprinting.

Keywords: In situ 3D bioprinting; Robotic bioprinting platform; Tissue engineering.

PubMed Disclaimer

Conflict of interest statement

The authors declare no known conflicts of interest.

Figures

See this image and copyright information in PMC

Cited by

Precision improvement of robotic bioprinting via vision-based tool path compensation.
Barjuei ES, Shin J, Kim K, Lee J. Barjuei ES, et al. Sci Rep. 2024 Aug 1;14(1):17764. doi: 10.1038/s41598-024-68597-z. Sci Rep. 2024. PMID: 39085375 Free PMC article.
Biomimetic Scaffolds-A Novel Approach to Three Dimensional Cell Culture Techniques for Potential Implementation in Tissue Engineering.
Górnicki T, Lambrinow J, Golkar-Narenji A, Data K, Domagała D, Niebora J, Farzaneh M, Mozdziak P, Zabel M, Antosik P, Bukowska D, Ratajczak K, Podhorska-Okołów M, Dzięgiel P, Kempisty B. Górnicki T, et al. Nanomaterials (Basel). 2024 Mar 16;14(6):531. doi: 10.3390/nano14060531. Nanomaterials (Basel). 2024. PMID: 38535679 Free PMC article. Review.
Recent Advances in Decellularized Extracellular Matrix-Based Bioinks for 3D Bioprinting in Tissue Engineering.
Zhe M, Wu X, Yu P, Xu J, Liu M, Yang G, Xiang Z, Xing F, Ritz U. Zhe M, et al. Materials (Basel). 2023 Apr 18;16(8):3197. doi: 10.3390/ma16083197. Materials (Basel). 2023. PMID: 37110034 Free PMC article. Review.
Improving Thermosensitive Bioink Scaffold Fabrication with a Temperature-Regulated Printhead in Robot-Assisted In Situ Bioprinting System.
Wang Z, Lin L, Li X, Zhang Q, Mi X, Xu B, Xu Y, Liu T, Shen Y, Wang Z, Xie N, Wang J. Wang Z, et al. ACS Omega. 2024 Sep 18;9(39):40618-40631. doi: 10.1021/acsomega.4c04373. eCollection 2024 Oct 1. ACS Omega. 2024. PMID: 39371970 Free PMC article.
Advancements in robotic arm-based 3D bioprinting for biomedical applications.
Li K, Huang W, Guo H, Liu Y, Chen S, Liu H, Gu Q. Li K, et al. Life Med. 2023 Nov 21;2(6):lnad046. doi: 10.1093/lifemedi/lnad046. eCollection 2023 Dec. Life Med. 2023. PMID: 39872062 Free PMC article. Review.

See all "Cited by" articles

References

1. Singh S, Choudhury D, Yu F, et al. In Situ Bioprinting-Bioprinting from Benchside to Bedside? Acta Biomater. 2020;2020;101:14–25. https://doi.org/10.1016/j.actbio.2019.08.045. - PubMed
1. Vijayavenkataraman S, Yan WC, Lu WF, et al. 3D Bioprinting of Tissues and Organs for Regenerative Medicine. Adv Drug Deliv Rev. 2018;132:296–332. https://doi.org/10.1016/j.addr.2018.07.004. - PubMed
1. Keriquel V, Guillemot F, Arnault I, et al. In Vivo Bioprinting for Computer and Robotic-assisted Medical Intervention:Preliminary Study in Mice. Biofabrication. 2020;2:014101. https://doi.org/10.1088/1758-5082/2/1/014101. - PubMed
1. Ding H, Chang RC. Simulating Image-guided In Situ Bioprinting of a Skin Graft onto a Phantom Burn Wound Bed. Addit Manuf. 2018;22:708–19. https://doi.org/10.1016/j.addma.2018.06.022.
1. Wang M, He J, Liu Y, et al. The Trend Towards In Vivo Bioprinting. Int J Bioprint. 2015;1:15–26. http://dx.doi.org/10.18063/IJB.2015.01.001.

Publication types

Actions

LinkOut - more resources

Full Text Sources
- Europe PubMed Central
- PubMed Central

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Research Progress of Robot Technology in In situ 3D Bioprinting

Affiliations

Research Progress of Robot Technology in In situ 3D Bioprinting

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

LinkOut - more resources

Full Text Sources