Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Jul 12;21(2):1895-1901.
doi: 10.1007/s40200-022-01086-0. eCollection 2022 Dec.

A Meta-analysis of ADIPOQ rs2241766 polymorphism association with type 2 diabetes

Yeganeh Hamidi  1 , Sahar Saki  2 , Elham Sadat Afraz  3 , Sanaz Pashapour  4
Affiliations
Review

A Meta-analysis of ADIPOQ rs2241766 polymorphism association with type 2 diabetes

Yeganeh Hamidi et al. J Diabetes Metab Disord. .

Abstract

Objective: There is extensive research on the association between polymorphisms in the adiponectin gene (ADIPOQ) and type 2 diabetes (T2D). The present meta-analytic study explored the association between ADIPOQ rs2241766 polymorphisms and T2D.

Metolds: Articles were collected by searching Google Scholar, Scopus, and PubMed electronic databases until 2021. They were searched using a systematic search of original and sensitive English keywords and their equivalent keywords based on the keywords "type 2 diabetes", "ADIPOQ", and "rs2241766". The article selection criteria were based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram.

Results: The results revealed that there was no bias in this study. Some studies, such as Joshaghani et al. (odds ratio [OR] = 2.18), Hussain et al. (OR = 2.12), Momin (OR = 4.45), and Amal et al. (OR = 1.84), showed an increasing effect of ADIPOQ rs266729 polymorphism on T2D with 95% CI (P ˂ 0.01), while some have shown no significant association between them.

Conclusion: The results of this meta-analytic study showed the relationship between ADIPOQ and rs2241766. Also, it was found that Rs2241766 polymorphism and allele increase the risk, and rs2241766 increases the risk of developing T2D (OR = 1.29).

Keywords: ADIPOQ; Adiponectin gene; Diabetes mellitus; Type 2 diabetes; rs2241766.

PubMed Disclaimer

Conflict of interest statement

Conflict of interestThe authors state that there is no conflict of interests regarding the publication of this article.

Figures

Fig. 1
Fig. 1
The process of selecting eligible articles
Fig. 2
Fig. 2
Association between rs2241766 gene polymorphism and the risk of T2D
Fig. 3
Fig. 3
The association of rs2241766 polymorphism with the risk of T2D
Fig. 4
Fig. 4
The funnel chart shows publication bias; the rate ratio is shown against the standard error. It is a symmetrical distribution, which indicates a lack of bias
See this image and copyright information in PMC

References

    1. Cho N, et al. IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271–281. doi: 10.1016/j.diabres.2018.02.023. - DOI - PubMed
    1. Marín-Peñalver JJ, et al. Update on the treatment of type 2 diabetes mellitus. World J Diabetes. 2016;7(17):354. doi: 10.4239/wjd.v7.i17.354. - DOI - PMC - PubMed
    1. Abuhendi N, et al. Genetic polymorphisms associated with type 2 diabetes in the Arab world: a systematic review and meta-analysis. Diabetes Res Clin Pract. 2019;151:198–208. doi: 10.1016/j.diabres.2019.03.037. - DOI - PubMed
    1. Wdowiak A, Farahmandlou N, Tajik A, et al. The cytotoxic effect of estradiol Valerate, progesterone, and testosterone on brain glioblastoma (A172), colorectal Cancer (HT29) and human embryonic kidney (HEK293) cells and the expression levels of Bax, Bcl-2, and KAI-1/CD82 in A172 and HT29 cells. J B S. 2021;4(3):106–119.
    1. Norouzi S, Ahmadi R, Pashapour S. The cytotoxic effects of Tolmetin on evaluation of Bax and Bcl2 genes expression level in cervical cancer cells (Hela) KAUMS J (FEYZ) 2020;24(1):31–37.

LinkOut - more resources