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Review
. 2022 Nov 16;10(32):11702-11711.
doi: 10.12998/wjcc.v10.i32.11702.

Overlap of diabetic ketoacidosis and hyperosmolar hyperglycemic state

Esraa Mamdouh Hassan  1 , Hisham Mushtaq  2 , Esraa Elaraby Mahmoud  3 , Sherley Chhibber  4 , Shoaib Saleem  5 , Ahmed Issa  6 , Jain Nitesh  1 , Abbas B Jama  1 , Anwar Khedr  7 , Sydney Boike  8 , Mikael Mir  8 , Noura Attallah  1 , Salim Surani  9   10 , Syed A Khan  1
Affiliations
Review

Overlap of diabetic ketoacidosis and hyperosmolar hyperglycemic state

Esraa Mamdouh Hassan et al. World J Clin Cases. .

Abstract

Diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemia state (HHS) are two life-threatening metabolic complications of diabetes that significantly increase mortality and morbidity. Despite major advances, reaching a uniform consensus regarding the diagnostic criteria and treatment of both conditions has been challenging. A significant overlap between these two extremes of the hyperglycemic crisis spectrum poses an additional hurdle. It has well been noted that a complete biochemical and clinical patient evaluation with timely diagnosis and treatment is vital for symptom resolution. Worldwide, there is a lack of large-scale studies that help define how hyperglycemic crises should be managed. This article will provide a comprehensive review of the pathophysiology, diagnosis, and management of DKA-HHS overlap.

Keywords: Diabetes; Diabetic ketoacidosis; Hypernatremia; Hyperosmolar Coma; Hyperosmolar hyperglycemia state; Metabolic acidosis.

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Conflict of interest statement

Conflict-of-interest statement: There are no conflicts of interest to report.

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