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. 2022 Nov 3:13:864633.
doi: 10.3389/fimmu.2022.864633. eCollection 2022.

Autoimmunity: Are we asking the right question?

Polly Matzinger  1
Affiliations

Autoimmunity: Are we asking the right question?

Polly Matzinger. Front Immunol. .

Abstract

For decades, the main question immunologists have asked about autoimmunity is "what causes a break in self-tolerance?" We have not found good answers to that question, and I believe we are still so ignorant because it's the wrong question. Rather than a break in self-tolerance, I suggest that many autoimmune diseases might be due to defects in normal tissue physiology.

Keywords: T helper cells (Th cells); autoimmunity; autoreactivity; pregnancy; programmed cell death, danger model; tissue resident cells; tissue-based class control.

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Conflict of interest statement

The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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