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. 2022 Nov 3:13:1033918.
doi: 10.3389/fpsyt.2022.1033918. eCollection 2022.

Heschl's gyrus duplication pattern and clinical characteristics in borderline personality disorder: A preliminary study

Tsutomu Takahashi  1   2 , Daiki Sasabayashi  1   2 , Dennis Velakoulis  3   4 , Michio Suzuki  1   2 , Patrick D McGorry  5   6 , Christos Pantelis  3   7   8 , Andrew M Chanen  5   6
Affiliations

Heschl's gyrus duplication pattern and clinical characteristics in borderline personality disorder: A preliminary study

Tsutomu Takahashi et al. Front Psychiatry. .

Abstract

Inter-individual variations in the sulco-gyral pattern of Heschl's gyrus (HG) might contribute to emotional processing. However, it remains largely unknown whether borderline personality disorder (BPD) patients exhibit an altered HG gyrification pattern, compared with healthy individuals, and whether such a brain morphological feature, if present, might contribute to their clinical characteristics. The present study used magnetic resonance imaging to investigate the distribution of HG gyrification patterns (single or duplicated) and their relationship to clinical characteristics in teenage BPD patients with minimal treatment exposure. No significant difference was noted for the prevalence of HG patterns between 20 BPD and 20 healthy participants. However, the BPD participants with left duplicated HG were characterized by higher prevalence of comorbid disruptive behavior disorders, with higher externalizing score compared with those with left single HG. Our preliminary results suggest that neurodevelopmental pathology associated with gyral formation might be implicated in the neurobiology of early BPD, especially for emotional and behavioral control.

Keywords: disruptive behavior disorders; externalizing behavior; gyrification; magnetic resonance imaging; sulco-gyral pattern; superior temporal gyrus.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Sample MR images of different gyrification pattern in the Heschl’s gyrus (HG) (colored in blue). These HG patterns have been demonstrated also in our previous publications (–26). A, anterior; CPD, complete posterior duplication; CSD, common stem duplication; FTS, first transverse sulcus; HS, Heschl’s sulcus; L, lateral; Lt, left; P, posterior; M, medial; PP, planum polare; Rt, right; sHG, second Heschl’s gyrus; sHS, second Heschl’s sulcus; SI, sulcus intermedius.
FIGURE 2
FIGURE 2
Distribution of Heschl’s gyrus (HG) duplication patterns in the healthy control (HC) and borderline personality disorder (BPD) groups. CPD, complete posterior duplication; CSD, common stem duplication. Error bars show 95% confidence intervals.
FIGURE 3
FIGURE 3
Youth Self-Report (YSR) or Young Adult Self-Report (YASR) externalizing scores in the borderline personality disorder patients with single and duplicated Heschl’s gyrus patterns on the left hemisphere. Horizontal bars indicate means of each group. *p < 0.05.
See this image and copyright information in PMC

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