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. 2022 Nov 2:13:989905.
doi: 10.3389/fpsyt.2022.989905. eCollection 2022.

Effects of non-invasive neurostimulation on autism spectrum disorder: A systematic review

Jiawei Zhang  1   2 , Hao Zhang  1   2   3   4
Affiliations

Effects of non-invasive neurostimulation on autism spectrum disorder: A systematic review

Jiawei Zhang et al. Front Psychiatry. .

Abstract

Non-invasive neurostimulation techniques (NIBS) have shown benefits in psychiatric conditions. While in ASD patients, no guideline has so-far been recommended on these techniques due to a lack of high-quality synthetic evidence. Here, a comprehensive search from database inception onward was conducted in PubMed, EMBASE, and Cochrane library. Sham-controlled studies assessing the effects of NIBS in ASD patients were identified. After screening, twenty-two studies were included. A total of 552 patients were involved, and the sample size ranged from 5 to 78 patients. Although an iteration from exploratory attempts to more strictly designed trials has been seen to evaluate the efficacy of NIBS on ASD, further trials should also be needed to enable the clinicians and researchers to reach any consensus.

Systematic review registration: [https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021292434], identifier [CRD42021292434].

Keywords: autism spectrum disorder; meta-analysis; noninvasive neurostimulation; systematic review; transcranial direct current stimulation; transcranial magnetic stimulation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Preferred Reporting Items for Systematic Reviews and Meta-Analyses diagram for the selection of papers.
FIGURE 2
FIGURE 2
Summary of risk-of-bias analysis.
See this image and copyright information in PMC

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