ESOT Consensus Platform for Organ Transplantation: Setting the Stage for a Rigorous, Regularly Updated Development Process

doi:10.3389/ti.2022.10915

Review

. 2022 Oct 24:35:10915.

doi: 10.3389/ti.2022.10915. eCollection 2022.

ESOT Consensus Platform for Organ Transplantation: Setting the Stage for a Rigorous, Regularly Updated Development Process

Umberto Cillo¹, Annemarie Weissenbacher², Liset Pengel³, Ina Jochmans^{4

5}, Daniele Roppolo⁶, Cristiano Amarelli⁷, Luca S Belli⁸, Marina Berenguer⁹, Aiko De Vries¹⁰, Joana Ferrer^{11

12

13

14}, John Friedewald¹⁵, Lucrezia Furian¹⁶, Sharlene Greenwood¹⁷, Diethard Monbaliu¹⁸, Silvio Nadalin¹⁹, Arne Neyrinck^{20

21}, Mario Strazzabosco²², Christian Toso²³, Gianluigi Zaza²⁴, Raj Thuraisingham²⁵, Thierry Berney^{26

27}, Luciano Potena²⁸, Nuria Montserrat^{29

30

31}, Nazia Selzner³²

Affiliations

¹ Chirurgia Generale 2, Epato-Bilio-Pancreatica e Centro Trapianto di Fegato, Azienda Ospedale Università Padova, Padova, Italy.
² Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Medical University of Innsbruck, Innsbruck, Austria.
³ Centre for Evidence in Transplantation, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
⁴ Transplantation Research Group, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.
⁵ Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium.
⁶ ESOT Office, Padova, Italy.
⁷ Ospedale Monaldi, Azienda dei Colli, Naples, Italy.
⁸ Hepatology and Gastroenterology Unit, ASST GOM Niguarda, Milan, Italy.
⁹ Liver Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
¹⁰ Division of Nephrology, Department of Medicine, Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Netherlands.
¹¹ Hepatobiliopancreatic Surgery and Liver and Pancreatic Transplantation Unit, Department of Surgery, Institute Clínic of Digestive and Metabolic Diseases (ICMDiM), Hospital Clínic, University of Barcelona, Barcelona, Spain.
¹² Barcelona Clínic Liver Cancer Group (BCLC), University of Barcelona, Barcelona, Spain.
¹³ August Pi i Sunyer Biomedical, Research Institute (IDIBAPS), University of Barcelona, Barcelona, Spain.
¹⁴ Network for Biomedical Research in Hepatic and Digestive Diseases (CIBERehd), Barcelona, Spain.
¹⁵ Division of Medicine and Surgery, Northwestern University, Chicago, IL, United States.
¹⁶ Kidney and Pancreas Transplantation Unit, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, Italy.
¹⁷ King's College Hospital NHS Trust, London, UK King's College London, London, United Kingdom.
¹⁸ Department of Abdominal Transplant Surgery, University Hospitals Leuven, Catholic University Leuven, Leuven, Belgium.
¹⁹ Department of General, Visceral and Transplant Surgery, University Hospital Tübingen, Tübingen, Germany.
²⁰ Department of Anesthesiology, University Hospitals Leuven, Leuven, Belgium.
²¹ Department of Cardiovascular Sciences, Catholic University Leuven, Leuven, Belgium.
²² Liver Center, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, United States.
²³ Division of Abdominal Surgery, Geneva University Hospitals, Geneva, Switzerland.
²⁴ Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
²⁵ Royal London Hospital, London, United Kingdom.
²⁶ School of Medicine, University of Geneva, Geneva, Switzerland.
²⁷ Ilia State University, Tbilisi, Georgia.
²⁸ Heart Failure and Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
²⁹ Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
³⁰ Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Barcelona, Spain.
³¹ Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
³² Ajmera Transplant Center, University of Toronto, Toronto, ON, Canada.

PMID: 36406781
PMCID: PMC9667481
DOI: 10.3389/ti.2022.10915

Review

ESOT Consensus Platform for Organ Transplantation: Setting the Stage for a Rigorous, Regularly Updated Development Process

Umberto Cillo et al. Transpl Int. 2022.

. 2022 Oct 24:35:10915.

doi: 10.3389/ti.2022.10915. eCollection 2022.

Authors

Affiliations

¹ Chirurgia Generale 2, Epato-Bilio-Pancreatica e Centro Trapianto di Fegato, Azienda Ospedale Università Padova, Padova, Italy.
² Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Medical University of Innsbruck, Innsbruck, Austria.
³ Centre for Evidence in Transplantation, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.
⁴ Transplantation Research Group, Department of Microbiology, Immunology, and Transplantation, KU Leuven, Leuven, Belgium.
⁵ Department of Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium.
⁶ ESOT Office, Padova, Italy.
⁷ Ospedale Monaldi, Azienda dei Colli, Naples, Italy.
⁸ Hepatology and Gastroenterology Unit, ASST GOM Niguarda, Milan, Italy.
⁹ Liver Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
¹⁰ Division of Nephrology, Department of Medicine, Leiden Transplant Center, Leiden University Medical Center, Leiden University, Leiden, Netherlands.
¹¹ Hepatobiliopancreatic Surgery and Liver and Pancreatic Transplantation Unit, Department of Surgery, Institute Clínic of Digestive and Metabolic Diseases (ICMDiM), Hospital Clínic, University of Barcelona, Barcelona, Spain.
¹² Barcelona Clínic Liver Cancer Group (BCLC), University of Barcelona, Barcelona, Spain.
¹³ August Pi i Sunyer Biomedical, Research Institute (IDIBAPS), University of Barcelona, Barcelona, Spain.
¹⁴ Network for Biomedical Research in Hepatic and Digestive Diseases (CIBERehd), Barcelona, Spain.
¹⁵ Division of Medicine and Surgery, Northwestern University, Chicago, IL, United States.
¹⁶ Kidney and Pancreas Transplantation Unit, Department of Surgical, Oncological and Gastroenterological Sciences, University of Padua, Padua, Italy.
¹⁷ King's College Hospital NHS Trust, London, UK King's College London, London, United Kingdom.
¹⁸ Department of Abdominal Transplant Surgery, University Hospitals Leuven, Catholic University Leuven, Leuven, Belgium.
¹⁹ Department of General, Visceral and Transplant Surgery, University Hospital Tübingen, Tübingen, Germany.
²⁰ Department of Anesthesiology, University Hospitals Leuven, Leuven, Belgium.
²¹ Department of Cardiovascular Sciences, Catholic University Leuven, Leuven, Belgium.
²² Liver Center, Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, United States.
²³ Division of Abdominal Surgery, Geneva University Hospitals, Geneva, Switzerland.
²⁴ Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
²⁵ Royal London Hospital, London, United Kingdom.
²⁶ School of Medicine, University of Geneva, Geneva, Switzerland.
²⁷ Ilia State University, Tbilisi, Georgia.
²⁸ Heart Failure and Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
²⁹ Pluripotency for Organ Regeneration, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.
³⁰ Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Barcelona, Spain.
³¹ Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
³² Ajmera Transplant Center, University of Toronto, Toronto, ON, Canada.

PMID: 36406781
PMCID: PMC9667481
DOI: 10.3389/ti.2022.10915

Abstract

The European Society for Organ Transplantation (ESOT) has created a platform for the development of rigorous and regularly updated evidence based guidelines for clinical practice in the transplantation field. A dedicated Guideline Taskforce, including ESOT-council members, a representative from the Centre for Evidence in Transplantation, editors of the journal Transplant International has developed transparent procedures to guide the development of guidelines, recommendations, and consensus statements. During ESOT's first Consensus Conference in November 2022, leading experts will present in-depth evidence based reviews of nine themes and will propose recommendations aimed at reaching a consensus after public discussion and assessment by an independent jury. All recommendations and consensus statements produced for the nine selected topics will be published including the entire evidence-based consensus-finding process. An extensive literature review of each topic was conducted to provide final evidence and/or expert opinion.

Keywords: consensus conference; guidelines; methodology; organ transplantation; platform.

Copyright © 2022 Cillo, Weissenbacher, Pengel, Jochmans, Roppolo, Amarelli, Belli, Berenguer, De Vries, Ferrer, Friedewald, Furian, Greenwood, Monbaliu, Nadalin, Neyrinck, Strazzabosco, Toso, Zaza, Thuraisingham, Berney, Potena, Montserrat and Selzner.

PubMed Disclaimer

Conflict of interest statement

IJ received speaker fees from XVIVO perfusion paid to her institution. IJ is an ESOT Councilor for which she receives no reimbursement. JFe is recipient of a grant supported by Instituto de Salud Carlos III (ISCIII) through the project “PI18/00161 (Optimization of pancreas transplant graft: A multicentric study of histo-morphological and functional characteristics of unaccepted organs.)” and co-funded by the European Union. AdV received in the past speaker and consultation fees from Astellas, Chiesi, Hansa, Novartis, Sandoz, CSL Behring all of which paid to his institution. AdV is chair of the Dutch Kidney Advisory Committee (Landelijk Overleg NierTransplantatie LONT) for which he receives no reimbursement. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

**FIGURE 1**
Topics selected by ESOT Guideline Taskforce (GT) for consensus conference, TLJ 3.0, Prague November 2022.

See this image and copyright information in PMC

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References

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[1] Waggoner J, Carline JD, Durning SJ. Is There a Consensus on Consensus Methodology? Descriptions and Recommendations for Future Consensus Research. Acad Med (2016) 91(5):663–8. 10.1097/ACM.0000000000001092 - DOI - PubMed

[2] Waggoner J, Carline JD, Durning SJ. Is There a Consensus on Consensus Methodology? Descriptions and Recommendations for Future Consensus Research. Acad Med (2016) 91(5):663–8. 10.1097/ACM.0000000000001092 - DOI - PubMed

[3] Corbie-Smith G, Wynn M, Richmond A, Rennie S, Green M, Hoover SM, et al. Stakeholder-driven, Consensus Development Methods to Design an Ethical Framework and Guidelines for Engaged Research. PLoS One (2018) 13(6):e0199451. 10.1371/journal.pone.0199451 - DOI - PMC - PubMed

[4] Corbie-Smith G, Wynn M, Richmond A, Rennie S, Green M, Hoover SM, et al. Stakeholder-driven, Consensus Development Methods to Design an Ethical Framework and Guidelines for Engaged Research. PLoS One (2018) 13(6):e0199451. 10.1371/journal.pone.0199451 - DOI - PMC - PubMed

[5] Murphy MK, Black NA, Lamping DL, McKee CM, Sanderson CF, Askham J, et al. Consensus Development Methods, and Their Use in Clinical Guideline Development. Health Technol Assess (1998) 2:1. 10.3310/hta2030 - DOI - PubMed

[6] Murphy MK, Black NA, Lamping DL, McKee CM, Sanderson CF, Askham J, et al. Consensus Development Methods, and Their Use in Clinical Guideline Development. Health Technol Assess (1998) 2:1. 10.3310/hta2030 - DOI - PubMed

[7] Institute of Medicine (US) Committee to Improve the National Institutes of Health Consensus Development Program. Consensus Development at the NIH: Improving the Program. Washington (DC): National Academies Press US; (1990). - PubMed

[8] Institute of Medicine (US) Committee to Improve the National Institutes of Health Consensus Development Program. Consensus Development at the NIH: Improving the Program. Washington (DC): National Academies Press US; (1990). - PubMed

[9] Black N, Murphy M, Lamping D, McKee M, Sanderson C, Askham J, et al. Consensus Development Methods: a Review of Best Practice in Creating Clinical Guidelines. J Health Serv Res Pol (1999) 4(4):236–48. 10.1177/135581969900400410 - DOI - PubMed

[10] Black N, Murphy M, Lamping D, McKee M, Sanderson C, Askham J, et al. Consensus Development Methods: a Review of Best Practice in Creating Clinical Guidelines. J Health Serv Res Pol (1999) 4(4):236–48. 10.1177/135581969900400410 - DOI - PubMed

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ESOT Consensus Platform for Organ Transplantation: Setting the Stage for a Rigorous, Regularly Updated Development Process

Affiliations

ESOT Consensus Platform for Organ Transplantation: Setting the Stage for a Rigorous, Regularly Updated Development Process

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