Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Oct;14(10):395-399.
doi: 10.14740/jocmr4792. Epub 2022 Oct 28.

Type 5 Cardiorenal Syndrome: An Underdiagnosed and Underrecognized Disease Process of the American Mother

Justin Ilagan  1 , Harshini Sahani  2 , Arif Bin Saleh  1 , Kameron Tavakolian  1 , Anton Mararenko  1 , Ndausung Udongwo  1 , Steven Douedi  1 , Vandan Upadhyaya  3 , Swapnil Patel  1 , Arman Mushtaq  1 , Brett Sealove  3 , David Gonzalez  4 , Arif Asif  1
Affiliations
Review

Type 5 Cardiorenal Syndrome: An Underdiagnosed and Underrecognized Disease Process of the American Mother

Justin Ilagan et al. J Clin Med Res. 2022 Oct.

Abstract

Cardiorenal syndrome (CRS) continues to be an area of concern due to the changing understanding of identification, pathophysiology and optimal management. Originally thought that diuretics were always the answer, recent literature has shed lights on the five major CRS subphenotypes, and while conceptual in their classifications, different strategies may be utilized to manage each type. The effect of CRS in pregnant women is largely under discussed and underappreciated as its own entity. Trials involving possible management, specifically utilizing serelaxin, a recombinant form of relaxin, have shown promising results but more data are needed to begin implementing it on a large scale.

Keywords: Cardiorenal syndrome; Pregnant women; Serelaxin; Type 5.

PubMed Disclaimer

Conflict of interest statement

None to declare.

Similar articles

See all similar articles

References

    1. Ives CW, Sinkey R, Rajapreyar I, Tita ATN, Oparil S. Preeclampsia-pathophysiology and clinical presentations: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020;76(14):1690–1702. doi: 10.1016/j.jacc.2020.08.014. - DOI - PubMed
    1. Report from nine maternal mortality review committees. n.d.). https://www.cdcfoundation.org/sites/default/files/files/ReportfromNineMM....
    1. Petersen EE, Davis NL, Goodman D, Cox S, Mayes N, Johnston E, Syverson C. et al. Vital signs: pregnancy-related deaths, United States, 2011-2015, and strategies for prevention, 13 States, 2013-2017. MMWR Morb Mortal Wkly Rep. 2019;68(18):423–429. doi: 10.15585/mmwr.mm6818e1. - DOI - PMC - PubMed
    1. Rangaswami J, Bhalla V, Blair JEA, Chang TI, Costa S, Lentine KL, Lerma EV. et al. Cardiorenal syndrome: classification, pathophysiology, diagnosis, and treatment strategies: a scientific statement from the American Heart Association. Circulation. 2019;139(16):e840–e878. doi: 10.1161/CIR.0000000000000664. - DOI - PubMed
    1. Di Lullo L, Bellasi A, Barbera V, Russo D, Russo L, Di Iorio B, Cozzolino M. et al. Pathophysiology of the cardio-renal syndromes types 1-5: An uptodate. Indian Heart J. 2017;69(2):255–265. doi: 10.1016/j.ihj.2017.01.005. - DOI - PMC - PubMed

LinkOut - more resources