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. 2022 Jun;22(2):75-78.
doi: 10.4314/ahs.v22i2.9.

Use of exchange blood transfusion in the management of severe COVID-19 infection in pregnancy: experience from Lagos, Nigeria

Affiliations

Use of exchange blood transfusion in the management of severe COVID-19 infection in pregnancy: experience from Lagos, Nigeria

Bosede Bukola Afolabi et al. Afr Health Sci. 2022 Jun.

Abstract

Coronavirus disease 2019 (COVID-19) presents with symptoms that may be mild or severe. The individual with the severe form of the disease usually presents with a constellation of respiratory symptoms typical of acute respiratory distress syndrome. In this report, we present our experience of the successful management of an oxygen-dependent pregnant woman with severe COVID-19 infection who had 2 sessions of partial exchange blood transfusion. We discussed the principles that informed this intervention and the need to adopt this novel approach in the care of severe COVID-19 infection.

Keywords: ARDS; COVID-19; EBT; Exchange blood transfusion and pregnancy; Nigeria.

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Figures

Figure 1
Figure 1
A – Chest Xray film at presentation showing multiple consolidations in the middle and lower zones predominantly and increased vascular markings B – Chest X-ray film at discharge showing subtle consolidations in the upper lung zones.
Figure 2
Figure 2
A – Patient red cells showing Heinz bodies pre-exchange transfusion X100 B – Patient red cells 4 days post-exchange transfusion (Heinz bodies hardly visible) X100

References

    1. Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A. Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients. AJR Am J Roentgenol. 2020;215(1):87–93. - PubMed
    1. Wenzhong L, Hualan L. COVID-19 Disease: ORF8 and surface glycoprotein inhibit heme metabolism by binding to porphyrin. Chem Rxiv. 2020 doi: 10.26434/chemrxiv.11938173.v3. Preprint. - DOI
    1. Cavezzi A, Troiani E, Corrao S. COVID-19: hemoglobin, iron, and hypoxia beyond inflammation. A narrative review. Clin Pract. 2020 May 28;10(2):1271. - PMC - PubMed
    1. Hirschhorn T, Stockwell BR. The development of the concept of ferroptosis. Free Radic Biol Med. 2019;133:130–143. PubMed. - PMC - PubMed
    1. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet Internet. 2020;395(10229):1054–1062. - PMC - PubMed

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