The therapeutic potential of natural products for treating pancreatic cancer

doi:10.3389/fphar.2022.1051952

Review

. 2022 Nov 2:13:1051952.

doi: 10.3389/fphar.2022.1051952. eCollection 2022.

The therapeutic potential of natural products for treating pancreatic cancer

Xia He¹, Ning Wang², Yu Zhang³, Xiaobo Huang², Yi Wang²

Affiliations

¹ Department of Pharmacy, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
² Department of Critical Care Medicine, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
³ Department of Surgery, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

PMID: 36408249
PMCID: PMC9666876
DOI: 10.3389/fphar.2022.1051952

Review

The therapeutic potential of natural products for treating pancreatic cancer

Xia He et al. Front Pharmacol. 2022.

. 2022 Nov 2:13:1051952.

doi: 10.3389/fphar.2022.1051952. eCollection 2022.

Authors

Xia He¹, Ning Wang², Yu Zhang³, Xiaobo Huang², Yi Wang²

Affiliations

¹ Department of Pharmacy, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
² Department of Critical Care Medicine, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
³ Department of Surgery, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

PMID: 36408249
PMCID: PMC9666876
DOI: 10.3389/fphar.2022.1051952

Abstract

Pancreatic cancer is one of the most malignant tumors of the digestive tract, with the poor prognosis and low 5-year survival rate less than 10%. Although surgical resection and chemotherapy as gemcitabine (first-line treatment) has been applied to the pancreatic cancer patients, the overall survival rates of pancreatic cancer are quite low due to drug resistance. Therefore, it is of urgent need to develop alternative strategies for its treatment. In this review, we summarized the major herbal drugs and metabolites, including curcumin, triptolide, Panax Notoginseng Saponins and their metabolites etc. These compounds with antioxidant, anti-angiogenic and anti-metastatic activities can inhibit the progression and metastasis of pancreatic cancer. Expecting to provide comprehensive information of potential natural products, our review provides valuable information and strategies for pancreatic cancer treatment.

Keywords: curcumin; natural products; panax notoginseng saponins; pancreatic cancer; toosendanin; triptolide.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

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[1] Al-Rabia M. W., Alhakamy N. A., Rizg W. Y., Alghaith A. F., Ahmed O. A. A., Fahmy U. A. (2022). Boosting curcumin activity against human prostatic cancer PC3 cells by utilizing scorpion venom conjugated phytosomes as promising functionalized nanovesicles. Drug Deliv. 29 (1), 807–820. 10.1080/10717544.2022.2048133 - DOI - PMC - PubMed

[2] Al-Rabia M. W., Alhakamy N. A., Rizg W. Y., Alghaith A. F., Ahmed O. A. A., Fahmy U. A. (2022). Boosting curcumin activity against human prostatic cancer PC3 cells by utilizing scorpion venom conjugated phytosomes as promising functionalized nanovesicles. Drug Deliv. 29 (1), 807–820. 10.1080/10717544.2022.2048133 - DOI - PMC - PubMed

[3] Awale S., Li F., Onozuka H., Esumi H., Tezuka Y., Kadota S. (2008). Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Bioorg. Med. Chem. 16 (1), 181–189. 10.1016/j.bmc.2007.10.004 - DOI - PubMed

[4] Awale S., Li F., Onozuka H., Esumi H., Tezuka Y., Kadota S. (2008). Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Bioorg. Med. Chem. 16 (1), 181–189. 10.1016/j.bmc.2007.10.004 - DOI - PubMed

[5] Banerjee S., Sangwan V., McGinn O., Chugh R., Dudeja V., Vickers S. M., et al. (2013). Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1. J. Biol. Chem. 288 (47), 33927–33938. 10.1074/jbc.M113.500983 - DOI - PMC - PubMed

[6] Banerjee S., Sangwan V., McGinn O., Chugh R., Dudeja V., Vickers S. M., et al. (2013). Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1. J. Biol. Chem. 288 (47), 33927–33938. 10.1074/jbc.M113.500983 - DOI - PMC - PubMed

[7] Benlloch M., Obrador E., Valles S. L., Rodriguez M. L., Sirerol J. A., Alcacer J., et al. (2016). Pterostilbene decreases the antioxidant defenses of aggressive cancer cells in vivo: A physiological glucocorticoids- and nrf2-dependent mechanism. Antioxid. Redox Signal. 24 (17), 974–990. 10.1089/ars.2015.6437 - DOI - PMC - PubMed

[8] Benlloch M., Obrador E., Valles S. L., Rodriguez M. L., Sirerol J. A., Alcacer J., et al. (2016). Pterostilbene decreases the antioxidant defenses of aggressive cancer cells in vivo: A physiological glucocorticoids- and nrf2-dependent mechanism. Antioxid. Redox Signal. 24 (17), 974–990. 10.1089/ars.2015.6437 - DOI - PMC - PubMed

[9] Bockhorn M., Uzunoglu F. G., Adham M., Imrie C., Milicevic M., Sandberg A. A., et al. (2014). Borderline resectable pancreatic cancer: A consensus statement by the international study group of pancreatic surgery (ISGPS). Surgery 155 (6), 977–988. 10.1016/j.surg.2014.02.001 - DOI - PubMed

[10] Bockhorn M., Uzunoglu F. G., Adham M., Imrie C., Milicevic M., Sandberg A. A., et al. (2014). Borderline resectable pancreatic cancer: A consensus statement by the international study group of pancreatic surgery (ISGPS). Surgery 155 (6), 977–988. 10.1016/j.surg.2014.02.001 - DOI - PubMed

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The therapeutic potential of natural products for treating pancreatic cancer

Affiliations

The therapeutic potential of natural products for treating pancreatic cancer

Authors

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Abstract

Conflict of interest statement

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Abstract

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