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. 1987 Jan;61(1):209-13.
doi: 10.1128/JVI.61.1.209-213.1987.

Productive, persistent infection of human colorectal cell lines with human immunodeficiency virus

A Adachi, S Koenig, H E Gendelman, D Daugherty, S Gattoni-Celli, A S Fauci, M A Martin

Productive, persistent infection of human colorectal cell lines with human immunodeficiency virus

A Adachi et al. J Virol. 1987 Jan.

Abstract

Thirteen adherent human non-lymphocyte cell lines were tested for their susceptibility to infection by human immunodeficiency virus. Productive infection could be demonstrated in three of five colorectal carcinoma cell lines examined; the other eight human non-lymphocyte cell lines were uninfectible. A susceptible colon carcinoma cell line (HT29), as well as normal colonic mucosa, was shown to contain a 3.0-kilobase species of poly(A)+ CD4 RNA, whereas uninfectible colon carcinoma and rhabdomyosarcoma cell lines synthesized no detectable T4 RNA. A persistently infected colon carcinoma cell line was established that continued to produce progeny human immunodeficiency virus for more than 10 weeks postinfection.

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References

    1. N Engl J Med. 1981 Dec 10;305(24):1425-31 - PubMed
    1. Science. 1986 Sep 5;233(4768):1089-93 - PubMed
    1. Ann Intern Med. 1983 Aug;99(2):208-20 - PubMed
    1. J Immunol Methods. 1983 Dec 16;65(1-2):137-45 - PubMed
    1. Science. 1984 Jul 6;225(4657):59-63 - PubMed