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Review
. 2022 Nov 4:13:1032343.
doi: 10.3389/fneur.2022.1032343. eCollection 2022.

Therapeutic strategies for intracerebral hemorrhage

Zhe Li  1   2   3 , Suliman Khan  1   2   3 , Yang Liu  1   2   3 , Ruixue Wei  1   2   3 , V Wee Yong  4 , Mengzhou Xue  1   2   3
Affiliations
Review

Therapeutic strategies for intracerebral hemorrhage

Zhe Li et al. Front Neurol. .

Abstract

Stroke is the second highest cause of death globally, with an increasing incidence in developing countries. Intracerebral hemorrhage (ICH) accounts for 10-15% of all strokes. ICH is associated with poor neurological outcomes and high mortality due to the combination of primary and secondary injury. Fortunately, experimental therapies are available that may improve functional outcomes in patients with ICH. These therapies targeting secondary brain injury have attracted substantial attention in their translational potential. Here, we summarize recent advances in therapeutic strategies and directions for ICH and discuss the barriers and issues that need to be overcome to improve ICH prognosis.

Keywords: intracerebral hemorrhage; neuroinflammation; neuronal death; secondary brain injury; therapeutic strategies.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The mechanisms of primary and secondary brain injury after intracerebral hemorrhage, and drug intervention.
See this image and copyright information in PMC

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References

    1. Krishnamurthi RV, Ikeda T, Feigin VL. Global, regional and country-specific burden of ischaemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage: a systematic analysis of the global burden of disease study 2017. Neuroepidemiology. (2020) 54:171–9. 10.1159/000506396 - DOI - PubMed
    1. Qureshi AI, Mendelow AD, Hanley DF. Intracerebral haemorrhage. Lancet. (2009) 373:1632–44. 10.1016/S0140-6736(09)60371-8 - DOI - PMC - PubMed
    1. Hankey GJ. The global and regional burden of stroke. Lancet Glob Health. (2013) 1:e239–40. 10.1016/S2214-109X(13)70095-0 - DOI - PubMed
    1. Malinova V, Iliev B, Mielke D, Rohde V. Intracerebral hemorrhage-score allows a reliable prediction of mortality in patients with spontaneous intracerebral hemorrhage managed by fibrinolytic therapy. Cerebrovasc Dis. (2019) 48:165–70. 10.1159/000504246 - DOI - PubMed
    1. Wang J. Preclinical and clinical research on inflammation after intracerebral hemorrhage. Prog Neurobiol. (2010) 92:463–77. 10.1016/j.pneurobio.2010.08.001 - DOI - PMC - PubMed

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