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Review
. 2023 Apr 1;28(2):71-75.
doi: 10.1097/MOT.0000000000001038. Epub 2022 Nov 17.

Normothermic regional perfusion for donation after circulatory death donors

Chetan Pasrija  1 , Yuliya Tipograf, Ashish S Shah, John M Trahanas
Affiliations
Review

Normothermic regional perfusion for donation after circulatory death donors

Chetan Pasrija et al. Curr Opin Organ Transplant. .

Abstract

Purpose of review: This review is intended to provide an update on the logistics, technique, and outcomes associated with normothermic regional perfusion (NRP), as well as provide a discussion of the associated ethical issues.

Recent findings: There has been renewed interest in utilizing NRP to increase quality and availability of organs from donation after circulatory death (DCD) donors. Our institution has increasing experience with thoraco-abdominal NRP (TA-NRP) in controlled DCD donors (cDCD), whereas abdominal NRP (A-NRP) has been used with success in both cDCD and uncontrolled DCD (uDCD). There is increasing evidence that NRP can be conducted in a practical and cost-efficient manner, and that the organ yield may be of better quality than standard direct procurement and perfusion (DPP).

Summary: NRP is increasingly successful and will likely prove to be a superior method for cDCD recovery. However, before TA-NRP can be widely accepted the ethical debate surrounding this technique must be settled.

Video abstract: http://links.lww.com/COOT/A11.

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References

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