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. 2023 Mar;22(3):921-931.
doi: 10.1111/jocd.15517. Epub 2022 Nov 21.

Comparing the application of various engineered xenografts for skin defects: A systematic review

Antoine Salloum  1 , Nagham Bazzi  2 , Stephen Squires  3 , Thomas Chu  4 , Paul Benedetto  3   5 , Anthony Benedetto  3   6
Affiliations

Comparing the application of various engineered xenografts for skin defects: A systematic review

Antoine Salloum et al. J Cosmet Dermatol. 2023 Mar.

Abstract

Introduction: Xenografts are a now a cornerstone in the management of wound dressings. Promising results were achieved since 1960 in the application of skin substitute for skin defects.

Objective: The objective of this study was to evaluate the efficacy of various xenografts.

Methods: A literature research was conducted using the following query: 'Porcine skin dermatology substitute', 'bovine skin dermatology substitute', 'xenograft skin substitute dermatology', 'xenografts skin defect', 'porcine skin defect', 'bovine skin defect'.

Results: The review yielded 35 articles pertaining to the topic. Main indications for porcine and bovine xenograft application were burn wounds and post-traumatic wounds, respectively. Mean discharge date or length of stay was at the 6th day after porcine application, and the time of graft healing was reported for 33.7% (n = 510) of patients. Promising results were seen with Matriderm and split-thickness skin graft. Most wounds achieved an excellent cosmetic result with full range of motion and a smooth contour appearance. A great variety of tissue substitutes exist, and the choice of graft application should depend on a patient's factors, product availability, wound type, size, and physician's factors.

Conclusion: In summary, xenografts are more economic and affordable but have higher risk of infections compared to allografts.

Keywords: dermal grafting; dermatology surgery; wound care; wound healing; xenograft.

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References

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