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. 2023 Feb 1;183(2):162-164.
doi: 10.1001/jamainternmed.2022.5268.

Trends in the Concurrent Prescription of Opioids and Gabapentin in the US, 2006 to 2018

Evan D Peet  1 , Beth Dana  2 , Flora Yaou Sheng  1 , David Powell  1 , Kanaka Shetty  3 , Bradley D Stein  4
Affiliations

Trends in the Concurrent Prescription of Opioids and Gabapentin in the US, 2006 to 2018

Evan D Peet et al. JAMA Intern Med. .
No abstract available

Plain language summary

This cohort study examines trends in concurrent gabapentin and opioid prescribing in the US, overall and by prescriber, patient, and county characteristics, between 2006 and 2018.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Peet reported receiving grant funding from the National Institutes of Health (NIH) during the conduct of the study. Dr Sheng reported receiving grant funding from the National Institute on Drug Abuse (NIDA) during the conduct of the study. Dr Powell reported receiving grant funding from the NIDA during the conduct of the study and from the Centers for Disease Control and Prevention and the NIDA outside the submitted work. Dr Stein reported receiving grant funding from the NIDA during the conduct of the study. No other disclosures were reported.

Figures

Figure.
Figure.. Prescribing Trends for Opioid Analgesics, Gabapentin, and Concurrent Use
OACG indicates overlapping opioid analgesic and gabapentin episodes.
See this image and copyright information in PMC

Comment in

References

    1. US Food and Drug Administration . FDA warns about serious breathing problems with seizure and nerve pain medicines gabapentin (Neurontin, Gralise, Horizant) and pregabalin (Lyrica, Lyrica CR). December 19, 2019. Accessed January 15, 2022.https://www.fda.gov/drugs/drug-safety-and-availability/fda-warns-about-s...
    1. Goodman CW, Brett AS. A clinical overview of off-label use of gabapentinoid drugs. JAMA Intern Med. 2019;179(5):695-701. doi: 10.1001/jamainternmed.2019.0086 - DOI - PubMed
    1. McDonagh MS, Selph SS, Buckley DI, et al. Nonopioid Pharmacologic Treatments for Chronic Pain. Agency for Healthcare Research and Quality; 2020. Report No. 20-EHC010. Accessed March 5, 2022. https://www.ncbi.nlm.nih.gov/books/NBK556277/ - PubMed
    1. Peckham AM, Fairman KA, Sclar DA. All-cause and drug-related medical events associated with overuse of gabapentin and/or opioid medications: a retrospective cohort analysis of a commercially insured US population. Drug Saf. 2018;41(2):213-228. doi: 10.1007/s40264-017-0595-1 - DOI - PubMed
    1. Finnerup NB, Attal N, Haroutounian S, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015;14(2):162-173. doi: 10.1016/S1474-4422(14)70251-0 - DOI - PMC - PubMed

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