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Review
. 2023 Feb;103(1):17-33.
doi: 10.1016/j.suc.2022.08.002. Epub 2022 Oct 18.

Clinical Trials in Breast Cancer: Practice Changing, Landmark with a Focus on More Current Trials

Rick D Vavolizza  1 , Emily P Rabinovich  2 , Max O Meneveau  1 , Shayna L Showalter  3
Affiliations
Review

Clinical Trials in Breast Cancer: Practice Changing, Landmark with a Focus on More Current Trials

Rick D Vavolizza et al. Surg Clin North Am. 2023 Feb.

Abstract

Randomized clinical trials have been essential in guiding the surgical and systemic treatment of breast cancer, with most focusing on de-escalation. Here, we discuss key clinical trials that have shaped the modern approach to the treatment of breast cancer, focusing on studies that are more recent.

Keywords: Axillary lymph node dissection; Breast conserving surgery; Current management of breast cancer; Landmark clinical trials; Local-regional recurrence; Radiation therapy; Sentinel node biopsy.

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Conflict of interest statement

Disclosure The authors have nothing to disclose.