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Review
. 2023 Jan;32(1):27-46.
doi: 10.1016/j.soc.2022.07.004. Epub 2022 Nov 3.

Clinical Trials That Have Informed the Modern Management of Breast Cancer

Laura K Krecko  1 , Meeghan A Lautner  2 , Lee G Wilke  3
Affiliations
Review

Clinical Trials That Have Informed the Modern Management of Breast Cancer

Laura K Krecko et al. Surg Oncol Clin N Am. 2023 Jan.

Abstract

Randomized controlled trials have informed the historical evolution of breast cancer management, distilling operative and nonoperative treatments to achieve disease control and improve survival while maximizing quality of life and minimizing complications. The authors describe landmark trials investigating and influencing the following aspects of breast cancer care: extent of breast surgery; axillary management; neoadjuvant and adjuvant therapies; and selection of chemotherapy versus endocrine therapy via application of genomic assays.

Keywords: Adjuvant; Axilla; Breast cancer; Chemotherapy; Clinical trials; Endocrine; Neoadjuvant.

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Conflict of interest statement

Disclosure L.G. Wilke: Founder and Minority Stock Owner Elucent Medical (not discussed in this publication). The remaining authors have nothing to disclose.

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