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Comment
. 2022 Dec;102(6):1212-1214.
doi: 10.1016/j.kint.2022.09.004.

Treating crescentic glomerulonephritis by targeting macrophages

Anqun Chen  1 , Kyung Lee  2 , John Cijiang He  3
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Treating crescentic glomerulonephritis by targeting macrophages

Anqun Chen et al. Kidney Int. 2022 Dec.

Abstract

Macrophage accumulation in the kidney is associated with the progression of crescentic glomerulonephritis (GN) and is mostly derived from circulating monocytes. FROUNT, a C-C motif chemokine receptor 2 (CCR2)-interacted protein, which is strongly expressed in monocytes/macrophages, enhances macrophage infiltration through CCR2-mediated chemotaxis. In this issue of the journal, Toda et al. reported that disulfiram, an inhibitor of FROUNT, attenuates GN by inhibition of the FROUNT-CCR2 interaction and macrophage migration and activation, suggesting a potential therapeutic role for crescentic GN.

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