Pharmacobezoar after overdose of isoniazid and rifampin

Abstract

In clinical toxicology, gastric endoscopic decontamination is rarely used, and only a few cases of pharmacobezoar removal after intentional ingestion of slow-release drugs have been described. Our case describes the use of gastric endoscopic decontamination to remove potential pharmacobezoar in an adolescent after ingestion of a lethal dose of isoniazid and rifampin, even long after gastric lavage. This technique allowed the removal of pharmacobezoars still present in the stomach while preventing further deterioration of the patient.

Keywords: Isoniazid; decontaminative gastroscopy; pediatric poisoning; pharmacobezoars; rifampicin; suicide attempts.