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Comment
. 2023 Jan 2;220(1):e20221732.
doi: 10.1084/jem.20221732. Epub 2022 Nov 22.

Lectin recruits pathogenic bugs

Charles R Schutt  1 , Sho Yamasaki  1   2
Affiliations
Comment

Lectin recruits pathogenic bugs

Charles R Schutt et al. J Exp Med. .

Abstract

Colitis is an irritable bowel disorder affecting about 7 million patients worldwide, but the causes are diverse and not fully understood. In this issue, Matute et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20211938) found that a stress-induced lectin, intelectin-1, recruits pathogenic bacteria to the gut and exacerbates colitis.

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Figures

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Insights from Charles R. Schutt and Sho Yamasaki.
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ITLN1-coated pathogenic bacteria thin the mucus layer, worsening colitis. In the healthy gut, a there is limited expression of the lectin ITLN1 and a thick mucus layer keeping the microbiota away from the intestinal epithelial cells (IECs). During colitis, the increase in ER stress increases the expression of ITLN1, which binds to A. muciniphila, an organism that can degrade the mucus layer in the gut. ITLN1-bound A. muciniphilia can be taken up into intestinal macrophages that produce TNF, increasing gut inflammation and worsening colitis.
See this image and copyright information in PMC

Comment on

  • Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila.
    Matute JD, Duan J, Flak MB, Griebel P, Tascon-Arcila JA, Doms S, Hanley T, Antanaviciute A, Gundrum J, Mark Welch JL, Sit B, Abtahi S, Fuhler GM, Grootjans J, Tran F, Stengel ST, White JR, Krupka N, Haller D, Clare S, Lawley TD, Kaser A, Simmons A, Glickman JN, Bry L, Rosenstiel P, Borisy G, Waldor MK, Baines JF, Turner JR, Blumberg RS. Matute JD, et al. J Exp Med. 2023 Jan 2;220(1):e20211938. doi: 10.1084/jem.20211938. Epub 2022 Nov 22. J Exp Med. 2023. PMID: 36413219 Free PMC article.

References

    1. Kerr, S.C., et al. . 2014. Am. J. Respir. Crit. Care Med. 10.1164/rccm.201312-2220LE - DOI
    1. Kobayashi, H., et al. . 2022. Endocr. J. 10.1507/endocrj.EJ21-0438 - DOI
    1. Lin, X., et al. . 2021. Front. Cardiovasc. Med. 10.3389/fcvm.2021.757926 - DOI - PMC - PubMed
    1. Matute, J.D., et al. . 2022. J. Exp. Med. 10.1084/jem.20211938 - DOI
    1. Nonnecke, E.B., et al. . 2021. Sci. Rep. 10.1038/s41598-021-92198-9 - DOI