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Review
. 2023 Jan 15:225:1049-1071.
doi: 10.1016/j.ijbiomac.2022.11.167. Epub 2022 Nov 19.

Circulatory long noncoding RNAs (circulatory-LNC-RNAs) as novel biomarkers and therapeutic targets in cardiovascular diseases: Implications for cardiovascular diseases complications

Seyed Mahdi Emami Meybodi  1 , Nafiseh Soleimani  2 , Abolfazl Yari  3 , Amin Javadifar  4 , Mohammad Tollabi  5 , Bahareh Karimi  6 , Mahmoud Emami Meybodi  7 , Seyedmostafa Seyedhossaini  8 , Peiman Brouki Milan  9 , Ali Dehghani Firoozabadi  10
Affiliations
Review

Circulatory long noncoding RNAs (circulatory-LNC-RNAs) as novel biomarkers and therapeutic targets in cardiovascular diseases: Implications for cardiovascular diseases complications

Seyed Mahdi Emami Meybodi et al. Int J Biol Macromol. .

Abstract

Cardiovascular diseases (CVDs) are a group of disorders with major global health consequences. The prevalence of CVDs continues to grow due to population-aging and lifestyle modifications. Non-coding RNAs (ncRNAs) as key regulators of cell signaling pathways have gained attention in the occurrence and development of CVDs. Exosomal-lncRNAs (exos-lncRNAs) are emerging biomarkers due to their high sensitivity and specificity, stability, accuracy and accessibility in the biological fluids. Recently, circulatory and exos-based-lncRNAs are emerging and novel bio-tools in various pathogenic conditions. It is worth mentioning that dysregulation of these molecules has been found in different types of CVDs. In this regard, we aimed to discuss the knowledge gaps and suggest research priorities regarding circulatory and exos-lncRNAs as novel bio-tools and therapeutic targets for CVDs.

Keywords: Biomarkers; CVDs; Circulatory long-non coding RNA; Exosomes; Therapeutics.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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