Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Nov 22;15(11):e250648.
doi: 10.1136/bcr-2022-250648.

Rare manifestation of hyperreactio luteinalis: when both the mother and baby girl are virilised

Wing Shan Queenie See  1 , Tin Yan Mimi Seto  2 , Wing-Kit Grace Poon  3 , Joanna Yuet-Ling Tung  4
Affiliations
Case Reports

Rare manifestation of hyperreactio luteinalis: when both the mother and baby girl are virilised

Wing Shan Queenie See et al. BMJ Case Rep. .

Abstract

Hyperreactio luteinalis is a benign, pregnancy-related condition with cystic enlargement of the ovaries and elevated androgen. However, only one-third of patients manifest as maternal virilisation and rarely does it cause fetal virilisation. Here, we report a virilised baby girl born to a virilised mother because of hyperreactio luteinalis. This case illustrates our management to maternal and fetal virilisation.

Keywords: Endocrinology; Materno-fetal medicine; Pregnancy.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Bilateral adnexal multi-separated cysts of the mother during caesarean section.
Figure 2
Figure 2
Serial maternal testosterone level. Source: Wing Shan Queenie See.
Figure 3
Figure 3
Approach to baby girl with virilisation. Source: Wing Shan Queenie See.
See this image and copyright information in PMC

References

    1. Malinowski AK, Sen J, Sermer M. Hyperreactio Luteinalis: maternal and fetal effects. J Obstet Gynaecol Can 2015;37:715–23. 10.1016/S1701-2163(15)30176-6 - DOI - PubMed
    1. Edell H, Shearkhani O, Rahmani MR, et al. . Incidentally found hyperreactio luteinalis in pregnancy. Radiol Case Rep 2018;13:1220–3. 10.1016/j.radcr.2018.08.022 - DOI - PMC - PubMed
    1. Lynn KN, Steinkeler JA, Wilkins-Haug LE, et al. . Hyperreactio luteinalis (enlarged ovaries) during the second and third trimesters of pregnancy: common clinical associations. J Ultrasound Med 2013;32:1285–9. 10.7863/ultra.32.7.1285 - DOI - PubMed
    1. Glinoer D, De Nayer P, Robyn C, et al. . Serum levels of intact human chorionic gonadotropin (HCG) and its free alpha and beta subunits, in relation to maternal thyroid stimulation during normal pregnancy. J Endocrinol Invest 1993;16:881–8. 10.1007/BF03348950 - DOI - PubMed
    1. Kaňová N, Bičíková M. Hyperandrogenic states in pregnancy. Physiol Res 2011;60:243–52. 10.33549/physiolres.932078 - DOI - PubMed

Publication types