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. 2023 Jan 11;227(2):179-182.
doi: 10.1093/infdis/jiac461.

Association of Endothelial Protein C Receptor (EPCR) rs867186 Gene Polymorphism With Increased Levels of Soluble EPCR and High Risk of Severe Malaria and Fatality in Beninese Children

Samuel Odarkwei Blankson  1   2 , Liliane Dikroh  3 , Patrick Tettey  3 , Bernard Tornyigah  1   3 , Rafiou Adamou  1   4 , Azizath Moussiliou  1   4 , Maroufou J Alao  5 , Annick Amoussou  6 , Caroline Padounou  7 , Jacqueline Milet  1 , Benedicta Ayiedu Mensah  3 , Yaw Aniweh  2 , Nicaise Tuikue Ndam  1   2 , Christian Roussilhon  8 , Rachida Tahar  1   2
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Association of Endothelial Protein C Receptor (EPCR) rs867186 Gene Polymorphism With Increased Levels of Soluble EPCR and High Risk of Severe Malaria and Fatality in Beninese Children

Samuel Odarkwei Blankson et al. J Infect Dis. .

Abstract

The endothelial protein C receptor (EPCR)-rs867186 G allele has been linked to high plasma levels of soluble EPCR (sEPCR) and controversially associated with either susceptibility or resistance to severe and cerebral malaria. In this study, quantitative enzyme-linked immunosorbent assay and sequencing were used to assess sEPCR levels and EPCR-rs867186 polymorphism in blood samples from Beninese children with different clinical presentations of malaria. Our findings show that sEPCR levels were higher at hospital admission than during convalescence and that EPCR-rs867186 G allele was associated with increased sEPCR plasma levels, malaria severity, and mortality rate (P < .001, P = .03, and P = .04, respectively), suggesting a role of sEPCR in the pathogenesis of severe malaria.

Keywords: EPCR; cerebral malaria; polymorphism; rs867186.

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Conflict of interest statement

Potential conflicts of interest. All authors: No reported conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

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