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Review
. 2022 Nov 21:117:e220200.
doi: 10.1590/0074-02760220200. eCollection 2022.

Family Herpesviridae and neuroinfections: current status and research in progress

Vanessa Cristine de Souza Carneiro  1 , Jéssica Gonçalves Pereira  1 , Vanessa Salete de Paula  1
Affiliations
Review

Family Herpesviridae and neuroinfections: current status and research in progress

Vanessa Cristine de Souza Carneiro et al. Mem Inst Oswaldo Cruz. .

Abstract

This article addresses the relationship between human herpesviruses (HHVs) and neuroinfections. Alphaherpesviruses, betaherpesviruses and gammaherpesviruses are neurotropic viruses that establish latency and exhibit reactivation capacity. Encephalitis and meningitis are common in cases of HHV. The condition promoted by HHV infection is a purported trigger for certain neurodegenerative diseases. Ongoing studies have identified an association between HSV-1 and the occurrence of Alzheimer's disease, multiple sclerosis and infections by HHV-6 and Epstein-Barr virus. In this review, we highlight the importance of research investigating the role of herpesviruses in the pathogenesis of diseases that affect the nervous system and describe other studies in progress.

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