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Review
. 2023 Mar;48(3):767-780.
doi: 10.1007/s11064-022-03820-9. Epub 2022 Nov 23.

Inhibition of A1 Astrocytes and Activation of A2 Astrocytes for the Treatment of Spinal Cord Injury

Jingxuan Wang #  1 , Cai Cheng #  1 , Zhongbing Liu #  1 , Yan Lin #  1 , Lingling Yang  1 , Zijun Zhang  1 , Xiaoduan Sun  1 , Meiling Zhou  2 , Pei Jing  3 , Zhirong Zhong  4   5
Affiliations
Review

Inhibition of A1 Astrocytes and Activation of A2 Astrocytes for the Treatment of Spinal Cord Injury

Jingxuan Wang et al. Neurochem Res. 2023 Mar.

Abstract

Spinal cord injury (SCI) is a serious injury to the central nervous system that causes significant physical and psychological trauma to the patient. SCI includes primary spinal cord injuries and secondary spinal cord injuries. The secondary injury refers to the pathological process or reaction after the primary injury. Although SCI has always been thought to be an incurable injury, the human nerve has the ability to repair itself after an injury. However, the reparability is limited because glial scar formation impedes functional recovery. There is a type of astrocyte that can differentiate into two forms of reactive astrocytes known as 'A1' and 'A2' astrocytes. A1 astrocytes release cytotoxic chemicals that cause neurons and oligodendrocytes to die and perform a harmful role. A2 astrocytes can produce neurotrophic factors and act as neuroprotectors. This article discusses ways to block A1 astrocytes while stimulating A2 astrocytes to formulate a new treatment for spinal cord injury.

Keywords: A1 astrocytes; A2 astrocytes; Microenvironmental; Spinal cord injury.

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References

    1. Perrouin-Verbe, Physical BJAo, Medicine R (2012) Epidemiology of traumatic spinal cord injury: new trends. Spinal cord 55:e165
    1. Letton RW (2011) Spine trauma. Fundamentals of pediatric surgery. Springer
    1. Devivo MJ (2012) Epidemiology of traumatic spinal cord injury: trends and future implications. Spinal Cord 50:365–372
    1. Okada S, Maeda T, Ohkawa Y, Harimaya K, Saiwai H, Kumamaru H, Matsumoto Y, Doi T, Ueta T, Shiba KJS (2009) Does ossification of the posterior longitudinal ligament affect the neurological outcome after traumatic cervical cord injury? Spine 34:1148–1152
    1. Anjum A, Yazid M, Daud MF, Idris J, Lokanathan YJIJoMS, (2020) Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms. Int J Mol Sci 21:7533

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