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. 2022 Nov 23;22(1):484.
doi: 10.1186/s12876-022-02518-0.

Global, regional, and national burden of cirrhosis and other chronic liver diseases due to alcohol use, 1990-2019: a systematic analysis for the Global Burden of Disease study 2019

Xiansheng Zhang #  1 , Xin Zhang #  2 , Meilian Liu  3 , Lin Zhu  3 , Zhuokai He  3
Affiliations

Global, regional, and national burden of cirrhosis and other chronic liver diseases due to alcohol use, 1990-2019: a systematic analysis for the Global Burden of Disease study 2019

Xiansheng Zhang et al. BMC Gastroenterol. .

Abstract

Background: To date, no study has evaluated trends in the burden of alcohol-induced cirrhosis and other chronic liver diseases based on the Global Burden of Diseases, Injuries, and Risk Factors (GBD) 2019 study. Herein, we report on the global burden of alcohol-induced cirrhosis and other chronic liver diseases in terms of age, sex, and sociodemographic index (SDI) from 1990 to 2019, based on analysis of GBD 2019 data.

Methods: The estimated annual percentage change (EAPC) was calculated to determine the trends in the age-standardized incidence and mortality rates and disability-adjusted life years (DALYs) for alcohol-induced cirrhosis and other chronic liver diseases.

Results: From 1990 to 2019, the global age-standardized incidence rate showed an upward trend (EAPC = 0.10), whereas the global age-standardized mortality rate and DALYs showed a downward trend (EAPC = - 0.88 and - 0.89, respectively). Low-(187.08 in 2019) and low-middle (178.11 in 2019)SDI regions had much higher age-standardized DALYs. Eastern Europe saw the largest increases in the age-standardized mortality rate and DALYs. Lithuania had the largest increase in mortalities caused by alcohol-induced cirrhosis and other chronic liver diseases(EAPC = 4.61). The age-standardized mortality rates and DALYs were higher in men than in women.

Conclusion: From 1990 to 2019, the age-standardized incidence rate of alcohol-induced cirrhosis and other chronic liver diseases increased globally; however, both the age-standardized mortality rate and DALYs caused by alcohol-induced cirrhosis and other chronic liver diseases showed decreasing trends. Future studies should devise preventive strategies for low and low-middle SDI regions, Eastern Europe, Lithuania, and other high-risk regions.

Keywords: Alcohol use; Chronic liver diseases; Cirrhosis; Disability-adjusted life years; Estimated annual percentage change.

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Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose.

Figures

Fig. 1
Fig. 1
The EAPC of cirrhosis and other chronic liver diseases due to alcohol use ASRs from 1990 to 2019, by sex and region. (A) The EAPC of ASIR. (B) The EAPC of ASDR. (C) The EAPC of age-standardized DALY rate. EAPC = estimated annual percentage change. ASRs = age-standardized rates. ASIR = age standardized incidence rate. ASDR = age standardized death rate. DALY = disability adjusted life-year
Fig. 2
Fig. 2
The global map of EAPC of cirrhosis and other chronic liver diseases due to alcohol use age-standardized rates from 1990 to 2019, by countries. (A) The EAPC of ASIR. (B) The EAPC of ASDR. (C) The EAPC of age-standardized DALY rate. EAPC = estimated annual percentage change. ASIR = age standardized incidence rate. ASDR = age standardized death rate. DALY = disability adjusted life-year
See this image and copyright information in PMC

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