Therapy related complications in plasmablastic lymphoma in immunocompetent individual

Abstract

Background: Plasmablastic lymphoma (PBL) is a rare and aggressive subtype of diffuse large B-cell lymphoma seen in immunocompromised individuals. It has a diffuse growth pattern, with no standard therapy and a poor survival rate. Due to overlap in presenting features with lymphoma and myeloma, PBL is often a diagnostic dilemma. We present a case of PBL in a young immunocompetent female who developed treatment associated complications.

Case report: A 36-year-old presented with a lesion extending from the oral cavity to the pharynx and involving the angle of the mandible. Radiology and laryngoscopy described a growth pattern that was diagnosed to be PBL on histopathology. The patient underwent chemotherapy using level II DA-EPOCH (dose-adjusted-etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin) and prophylactic granulocyte-colony stimulating factor along with radiotherapy and ultimately, achieved metabolic response. However, she developed several episodes of paralytic ileus, cytopenia, oral ulcers, dermatitis and long-standing hypothyroidism as therapy-related complications and has been on treatment for the same ever since.

Conclusions: Thus, a high index of suspicion is necessary for early diagnosis and rapid initiation of therapy. Further, there is a need to detect and address therapy related complications early to prevent long-standing, therapy-related side effects from developing and deteriorating the patient's quality of life.

Keywords: Plasmablastic lymphoma; immunocompetent; oral cavity; therapy related complications.

Figure 1

H&E section of biopsy from base of tongue showing sheets of atypical lymphoid cells (Mark 1) admixed with plasmacytoid and mature plasma cells (Mark 2). Atypical cells are intermediate to large sized with round eccentric nuclei, prominent nucleoli and moderate amount of cytoplasm. Increased mitotic figures and apoptotic bodies present. No necrosis or angio-destruction could be seen (400×).