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Case Reports
. 2022 Nov 7:12:1038774.
doi: 10.3389/fonc.2022.1038774. eCollection 2022.

Case report: EML4::NTRK3 gene fusion in a patient with metastatic lung adenocarcinoma successfully treated with entrectinib

Chiara Lazzari  1 , Lorenza Pecciarini  2 , Claudio Doglioni  2 , Federica Pedica  2 , Ana Maria Samanes Gajate  3 , Alessandra Bulotta  4 , Vanesa Gregorc  1 , Maria Giulia Cangi  2
Affiliations
Case Reports

Case report: EML4::NTRK3 gene fusion in a patient with metastatic lung adenocarcinoma successfully treated with entrectinib

Chiara Lazzari et al. Front Oncol. .

Abstract

Rearrangements involving the neurotrophin kinase (NTRK) genes NTRK1, NTRK2 and NTRK3 with different fusion partners have been observed in both adult and pediatric solid tumors. Larotrectinib and entrectinib have been the first tumor-agnostic compounds approved for the treatment of NTRK fusion-positive tumors. Here, we report the first case of a female patient with a diagnosis of stage IV lung adenocarcinoma harboring the EML4::NTRK3 gene fusion, and successfully treated with entrectinib.

Keywords: EML4::NTRK3 fusion; NGS; NSCLC; NTRK; entrectinib.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
(A) PET scan at baseline showing the presence of lesions at the lung and the and mediastinal lymph nodes; (B) Magnetic brain resonance at baseline showing the presence of multiple brain metastases.
Figure 2
Figure 2
(A) Hematoxylin and eosin staining of acinar and solid adenocarcinoma grade 2 of the lung; (B, C) Interphase dual color break apart FISH using a NTRK3 probe (B) and a EML4 probe (C) displayed one normal orange/green fusion signal and one single orange signal and one single green signal in the majority of the neoplastic nuclei, indicating a rearrangement of both NTRK3 and EML4; (D) Immunohistochemistry staining with panTRK antibody (Roche).
Figure 3
Figure 3
PET scan showing a partial response following 2 months of therapy.
Figure 4
Figure 4
Timeline showing the clinical history of the patient.
See this image and copyright information in PMC

References

    1. Ganti AK, Klein AB, Cotarla I, Seal B, Chou E. Update of incidence, prevalence, survival, and initial treatment in patients with non–small cell lung cancer in the US. JAMA Oncol (2021) 7(12):1824–32. doi: 10.1001/jamaoncol.2021.4932 - DOI - PMC - PubMed
    1. Rosell R, Karachaliou N. Large-Scale screening for somatic mutations in lung cancer. Lancet. (2016) 387(10026):1354–6. doi: 10.1016/S0140-6736(15)01125-3 - DOI - PubMed
    1. Harada D, Takigawa N. Oligoprogression in non-small cell lung cancer. Cancers. (2021) 13(22):5823. doi: 10.3390/cancers13225823 - DOI - PMC - PubMed
    1. Schiavo Lena M, Cangi MG, Pecciarini L, Francaviglia I, Grassini G, Maire R, et al. . Evidence of a common cell origin in a case of pancreatic mixed intraductal papillary mucinous neoplasm-neuroendocrine tumor. Virchows Arch (2021) 478(6):1215–9. doi: 10.1007/s00428-020-02942-1 - DOI - PubMed
    1. Solomon JP, Linkov I, Rosado A, Mullaney K, Rosen EY, Frosina D, et al. . NTRK fusion detection across multiple assays and 33,997 cases: Diagnostic implications and pitfalls. Mod Pathol (2020) 33(1):38–46. doi: 10.1038/s41379-019-0324-7 - DOI - PMC - PubMed

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