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. 2022 Oct 15;13(5):49-53.
eCollection 2022.

Concurrent monkeypox and COVID-19: role of interleukin-1 receptor antagonist-like protein mechanism

Rujittika Mungmunpuntipantip  1 , Viroj Wiwanitkit  2   3   4   5
Affiliations

Concurrent monkeypox and COVID-19: role of interleukin-1 receptor antagonist-like protein mechanism

Rujittika Mungmunpuntipantip et al. Int J Biochem Mol Biol. .

Abstract

Objective: In 2022, monkeypox becomes a new global public health threat. Monkeypox has been present in Africa for a very long time. The COVID-19 epidemic has been affecting this region for some years. The outbreak state persists. The coexistence of the two diseases is an intriguing discovery. There is no documentation of the co-occurrence.

Methods: The possibility of coexisting of the two lethal illnesses, monkeypox and COVID-19, is an intriguing scientific subject. Using bioinformatic pathophysiological pathway analysis, the authors investigated the pathophysiological pathways of COVID-19 and monkeypox.

Results: The most common pathway was identified. An interleukin-1 receptor antagonist-like protein has been identified as a common pathway between the pathogenic processes of monkeypox and COVID-19.

Conclusion: The findings could explain why severe COVID-19 and monkeypox do not coexist.

Keywords: COVID-19; Monkeypox; antagonist; interleukin; receptor.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Interrelationship network showing the interrelationship between pathophysiological process of monkeypox and COVID-19 at the interleukin-1 receptor antagonist-like protein.
See this image and copyright information in PMC

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