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Review
. 2022 Nov 18;15(11):1430.
doi: 10.3390/ph15111430.

Osmotic Pump Drug Delivery Systems-A Comprehensive Review

Yosif Almoshari  1
Affiliations
Review

Osmotic Pump Drug Delivery Systems-A Comprehensive Review

Yosif Almoshari. Pharmaceuticals (Basel). .

Abstract

In the last couple of years, novel drug delivery systems (NDDS) have attracted much attention in the food and pharmaceutical industries. NDDS is a broad term that encompasses many dosage forms, one of which is osmotic pumps. Osmotic pumps are considered to be the most reliable source of controlled drug delivery, both in humans and in animals. These pumps are osmotically controlled and release active agents through osmotic pressure. To a large extent, drug release from such a system is independent of gastric fluids. Based on such unique properties and advantages, osmotic pumps have made their mark on the pharmaceutical industry. This review summarizes the available osmotic devices for implantation and osmotic tablets for oral administration.

Keywords: controlled release system; novel drug delivery system; osmosis; osmotic pressure; osmotic pump.

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Conflict of interest statement

The author (YA) declares no conflict of interest.

Figures

Figure 1
Figure 1
Classification of osmotic delivery systems.
Figure 2
Figure 2
The Rose–Nelson pump.
Figure 3
Figure 3
The Higuchi–Leeper pump.
Figure 4
Figure 4
The Higuchi–Theeuwes pump.
Figure 5
Figure 5
The structure of an EOP.
Figure 6
Figure 6
Push–pull osmotic pump.
Figure 7
Figure 7
Sandwiched osmotic tablet.
Figure 8
Figure 8
Controlled-porosity osmotic pump.
Figure 9
Figure 9
Telescopic capsule for delayed release.
See this image and copyright information in PMC

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