The influenza universe in an mRNA vaccine

Alyson A Kelvin^{1

2}, Darryl Falzarano^{1

3}

Affiliations

¹ Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
² Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
³ Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Comment

Alyson A Kelvin et al. Science. 2022.

. 2022 Nov 25;378(6622):827-828.

doi: 10.1126/science.adf0900. Epub 2022 Nov 24.

Alyson A Kelvin^{1

2}, Darryl Falzarano^{1

3}

¹ Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
² Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
³ Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

Abstract

An mRNA-lipid nanoparticle vaccine protects animals from 20 influenza lineages.

A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes.
Arevalo CP, Bolton MJ, Le Sage V, Ye N, Furey C, Muramatsu H, Alameh MG, Pardi N, Drapeau EM, Parkhouse K, Garretson T, Morris JS, Moncla LH, Tam YK, Fan SHY, Lakdawala SS, Weissman D, Hensley SE. Arevalo CP, et al. Science. 2022 Nov 25;378(6622):899-904. doi: 10.1126/science.abm0271. Epub 2022 Nov 24. Science. 2022. PMID: 36423275 Free PMC article.