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. 2023 Jan;20(1):e202200631.
doi: 10.1002/cbdv.202200631. Epub 2022 Dec 8.

Caesalpinia palmeri: First Report on the Phenolic Compounds Profile, Antioxidant and Cytotoxicity Effect

J C López-Romero  1 , H Torres-Moreno  1 , M Vidal-Gutiérrez  2 , G G Cabrera-Cabrera  1 , R E Robles-Zepeda  3 , K L Rodríguez-Martínez  4 , J Ortega-García  1 , M A Villegas-Ochoa  5 , Norma J Salazar-López  6 , J Abraham Domínguez-Avila  7 , G A González-Aguilar  5
Affiliations

Caesalpinia palmeri: First Report on the Phenolic Compounds Profile, Antioxidant and Cytotoxicity Effect

J C López-Romero et al. Chem Biodivers. 2023 Jan.

Abstract

This study aimed to determine the phenolic compounds profile, antioxidant potential and cytotoxicity of extracts and fractions of Caesalpinia palmeri. Methanolic extracts were generated from C. palmeri berries, stems and flowers. The latter was subjected to liquid-liquid partition, obtaining hexane, ethyl acetate and residues fractions. Results showed that the flower extract and ethyl acetate fraction had a larger concentration of phenolic compounds (148.9 and 307.9 mg GAE/g, respectively), being ellagic acid (6233.57 and 19550.08 μg/g, respectively), quercetin-3-β-glycoside (3023.85 and 8952.55 μg/g, respectively) and gallic acid (2212.98 and 8422.34 μg/g, respectively) the most abundant compounds. Flower extract and ethyl acetate fraction also presented the highest antioxidant capacity on all tested methods (DPPH, ABTS, ORAC and FRAP) and low cytotoxicity against ARPE-19 cells (IC50 >170 μg/mL). C. palmeri possessed high antioxidant potential, associated with the presence of phenolic compounds and low cytotoxicity, suggesting that they could represent an option to counter oxidative stress.

Keywords: Caesalpinia palmeri; antioxidants; cytotoxicity; phenolic compounds.

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References

    1. T. Kawamura, I. Muraoka, ‘Exercise-induced oxidative stress and the effects of antioxidant intake from a physiological viewpoint’, Antioxidants 2018, 7, 1-19.
    1. H. Yaribeygi, S. L. Atkin, A. Sahebkar, ‘A review of the molecular mechanisms of hyperglycemia-induced free radical generation leading to oxidative stress’, J. Cell. Physiol. 2019, 234, 1300-1312.
    1. S. Prasad, S. K. Srivastava, ‘Oxidative stress and cancer: chemopreventive and therapeutic role of triphala’, Antioxidants 2020, 9, 1-15.
    1. R. K. Gupta, A. K. Patel, N. Shah, A. K. Choudhary, U. K. Jha, U. C. Yadav, U. Pakuwal, ‘Oxidative stress and antioxidants in disease and cancer: a review’, Asian Pac. J. Cancer Prev. 2014, 15, 4405-4409.
    1. J. Gao, J. Hu, D. Hu, X. Yang, ‘A role of gallic acid in oxidative damage diseases: a comprehensive review’, Nat. Prod. Commun. 2019, 14, 1-9.

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