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Comment
. 2022 Nov 23;185(24):4467-4469.
doi: 10.1016/j.cell.2022.10.029.

Need for speed: Key driver of host cell migration varies among mycobacteria

Madison A Youngblom  1 , Caitlin S Pepperell  2
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Comment

Need for speed: Key driver of host cell migration varies among mycobacteria

Madison A Youngblom et al. Cell. .
Free article

Abstract

In this issue of Cell, Saelens et al. describe a new function for mycobacterial Type VII secretion systems: manipulation of host cell migration. They find that a substantial proportion of global TB cases arise from bacteria lacking this function, raising questions about its role in pathoadaptation of Mycobacterium tuberculosis.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • An ancestral mycobacterial effector promotes dissemination of infection.
    Saelens JW, Sweeney MI, Viswanathan G, Xet-Mull AM, Jurcic Smith KL, Sisk DM, Hu DD, Cronin RM, Hughes EJ, Brewer WJ, Coers J, Champion MM, Champion PA, Lowe CB, Smith CM, Lee S, Stout JE, Tobin DM. Saelens JW, et al. Cell. 2022 Nov 23;185(24):4507-4525.e18. doi: 10.1016/j.cell.2022.10.019. Epub 2022 Nov 9. Cell. 2022. PMID: 36356582 Free PMC article.

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