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Comment
. 2022 Nov 23;185(24):4471-4473.
doi: 10.1016/j.cell.2022.10.026.

CAR T therapy extends its reach to autoimmune diseases

Daniel J Baker  1 , Carl H June  2
Affiliations
Free article
Comment

CAR T therapy extends its reach to autoimmune diseases

Daniel J Baker et al. Cell. .
Free article

Abstract

CAR T therapy has revolutionized the treatment of hematologic cancers. In their recent Nature Medicine paper, Mackensen et al. report the use of CAR T cells to treat systemic lupus erythematosus in five patients. This provides enthusiasm to further explore CAR T therapy beyond oncology.

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Conflict of interest statement

Declaration of interests C.H.J. is an inventor on patents and/or patent applications licensed to Novartis Institutes of Biomedical Research and receives license revenue from such licenses. C.H.J is a scientific founder of Tmunity Therapeutics and Capstan Therapeutics. C.H.J is a member of the scientific advisory boards of AC Immune, Alaunos, BluesphereBio, Cabaletta, Carisma, Cartography, Cellares, Celldex, Decheng, Poseida, Verismo, and WIRB-Copernicus.

Comment on

  • Anti-CD19 CAR T cell therapy for refractory systemic lupus erythematosus.
    Mackensen A, Müller F, Mougiakakos D, Böltz S, Wilhelm A, Aigner M, Völkl S, Simon D, Kleyer A, Munoz L, Kretschmann S, Kharboutli S, Gary R, Reimann H, Rösler W, Uderhardt S, Bang H, Herrmann M, Ekici AB, Buettner C, Habenicht KM, Winkler TH, Krönke G, Schett G. Mackensen A, et al. Nat Med. 2022 Oct;28(10):2124-2132. doi: 10.1038/s41591-022-02017-5. Epub 2022 Sep 15. Nat Med. 2022. PMID: 36109639

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