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. 2022 Nov 25;10(1):50.
doi: 10.1186/s40635-022-00478-z.

Knowledge gaps and research priorities in adult veno-arterial extracorporeal membrane oxygenation: a scoping review

Senta Jorinde Raasveld  1 , Carolien Volleman  1   2 , Alain Combes  3   4 , Lars Mikael Broman  5   6 , Fabio Silvio Taccone  7 , Elma Peters  8 , Sanne Ten Berg  8 , Charissa E van den Brom  1   2   9 , Holger Thiele  10 , Roberto Lorusso  11 , José P S Henriques  8 , Alexander P J Vlaar  12
Affiliations

Knowledge gaps and research priorities in adult veno-arterial extracorporeal membrane oxygenation: a scoping review

Senta Jorinde Raasveld et al. Intensive Care Med Exp. .

Abstract

Purpose: This scoping review aims to identify and describe knowledge gaps and research priorities in veno-arterial extracorporeal membrane oxygenation (VA-ECMO).

Methods: An expert panel was recruited consisting of eight international experts from different backgrounds. First, a list of priority topics was made. Second, the panel developed structured questions using population, intervention, comparison and outcomes (PICO) format. All PICOs were scored and prioritized. For every selected PICO, a structured literature search was performed.

Results: After an initial list of 49 topics, eight were scored as high-priority. For most of these selected topics, current literature is limited to observational studies, mainly consisting of retrospective cohorts. Only for ECPR and anticoagulation, randomized controlled trials (RCTs) have been performed or are ongoing. Per topic, a summary of the literature is stated including recommendations for further research.

Conclusions: This scoping review identifies and presents an overview of knowledge gaps and research priorities in VA-ECMO. Current literature is mostly limited to observational studies, although with increasing attention for this patient population, more RCTs are finishing or ongoing. Translational research, from preclinical trials to high-quality or randomized controlled trials, is important to improve the standard practices in this critically ill patient population. Take-home message This scoping review identifies and presents an overview of research gaps and priorities in VA-ECMO. Translational research, from preclinical trials to high-quality or randomized controlled trials, is important to improve the standard practices in this critically ill patient population.

Keywords: Extracorporeal cardiopulmonary resuscitation; Research gaps; Veno-arterial extracorporeal membrane oxygenation.

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Conflict of interest statement

No competing interests were stated by all authors.

Figures

Fig. 1
Fig. 1
Priority topics further elaborated in this review. From left to right: a percutaneous versus surgical methods of cannulation, b anticoagulant therapies, c blood transfusion regimen, d daily therapy goals, e ECPR selection criteria, f cardiogenic shock, g optimal balance of blood pressure and vasoactive medication, h endothelial activation and damage. © Myrthe Raasveld
See this image and copyright information in PMC

References

    1. ELSO (2017) General Guidelines for all ECLS Cases. ELSO Guidel 1–26
    1. Extracorporeal Life Support Organization ELSO International Summary of Statistics | ECMO | ECLS. ECLS Regist Rep. 2022;2022:1–1.
    1. Ouweneel DM, Schotborgh JV, Limpens J, et al. Extracorporeal life support during cardiac arrest and cardiogenic shock: a systematic review and meta-analysis. Intensive Care Med. 2016;42:1922–1934. doi: 10.1007/s00134-016-4536-8. - DOI - PMC - PubMed
    1. Naidu SS, Baran DA, Jentzer JC, et al. SCAI SHOCK stage classification expert consensus update: a review and incorporation of validation studies: this statement was endorsed by the American College of Cardiology (ACC), American College of Emergency Physicians (ACEP), American Heart Association. J Am Coll Cardiol. 2022;79:933–946. doi: 10.1016/j.jacc.2022.01.018. - DOI - PubMed
    1. McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021;42:3599–3726. doi: 10.1093/eurheartj/ehab368. - DOI - PubMed

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