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Case Reports
. 2022 Nov 8:9:1042262.
doi: 10.3389/fmed.2022.1042262. eCollection 2022.

An extremely rare case of malignant jejunal mesenteric inflammatory myofibroblastic tumor in a 61-year-old male patient: A case report and literature review

Hamdi Al Shenawi  1 , Salamah A Al-Shaibani  2 , Suhair K Al Saad  1 , Fedaa Al-Sindi  3 , Khalid Al-Sindi  3 , Noor Al Shenawi  2 , Yahya Naguib  4   5 , Rami Yaghan  1   6
Affiliations
Case Reports

An extremely rare case of malignant jejunal mesenteric inflammatory myofibroblastic tumor in a 61-year-old male patient: A case report and literature review

Hamdi Al Shenawi et al. Front Med (Lausanne). .

Abstract

Introduction: A mesenteric inflammatory myofibroblastic tumor (IMT) is a rare solid tumor of intermediate malignant potential that affects children, adolescents, and young adults predominantly. IMT is mostly encountered in the lung. We report a case of malignant jejunal mesenteric IMT in a 61-year-old male patient who presented with vague abdominal pain and generalized weakness. CT scan revealed a mesenteric mass displacing the attached jejunum. Surgical resection was curative.

Discussion: An extensive literature review was performed to update and further analyze the already available data. A total of 35 cases with mesenteric IMT were reported previously. Only five cases of jejunal mesenteric IMT were reported. Mesenteric IMT demands vast effort to reveal the diagnosis due to its vagueness in the clinical presentation. Mesenteric IMT resembles each other in plenty of pathological and immunohistochemical characteristics.

Conclusion: To the best of our knowledge, this is the first case of malignant jejunal mesenteric IMT in the elderly. Surgical resection was curative.

Keywords: inflammatory; jejunum; mass; mesenchymal; mesentery; myofibroblastic; stromal; tumor.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
CT scan of the abdomen, coronal, and axial images shows large well-defined opacity at mesentery on the left side of the upper abdomen surrounded by small and large bowel loops with no enlarged mesenteric or retroperitoneal lymph nodes.
FIGURE 2
FIGURE 2
Gross image of the tumor with associated bowel loop.
FIGURE 3
FIGURE 3
Microscopic image of intact jejunal bowel adjacent to tumor site, LPF.
FIGURE 4
FIGURE 4
Microscopic image of loosely arranged spindle cells growing in haphazardly arranged fascicles, interspersed by abundant chronic inflammatory cells, LPF.
FIGURE 5
FIGURE 5
Microscopic image of abundant chronic mononuclear and inflammatory cells, mostly lymphocytes, plasma cells, and histiocytes accompanied by eosinophils and scanty lymphoid aggregations, HPF.
See this image and copyright information in PMC

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References

    1. İçmeli ÖS, Alpay LA, Gündoğuş B, Türker H, Şen A. Inflammatory myofibroblastic tumor: a rare tumor of the lung. Eur Clin Respir J. (2014) 1. 10.3402/ecrj.v1.25390 - DOI - PMC - PubMed
    1. Mahajan P, Casanova M, Ferrari A, Fordham A, Trahair T, Venkatramani R. Inflammatory myofibroblastic tumor: molecular landscape, targeted therapeutics, and remaining challenges. Curr Probl Cancer. (2021) 45:100768. 10.1016/j.currproblcancer.2021.100768 - DOI - PubMed
    1. Han Q, He X, Cui L, Qiu Y, Li Y, Chen H, et al. Case report: early distant metastatic inflammatory myofibroblastic tumor harboring EML4-ALK fusion gene: study of two typical cases and review of literature. Front Med. (2022) 9:826705. 10.3389/fmed.2022.826705 - DOI - PMC - PubMed
    1. Cantera JE, Alfaro MP, Rafart DC, Zalazar R, Muruzabal MM, Barquín PG, et al. Inflammatory myofibroblastic tumours: a pictorial review. Insights Imaging. (2015) 6:85–96. - PMC - PubMed
    1. Gupta A, Sharma S, Mittal A, Barwad A, Rastogi S. Recurrent infantile inflammatory myofibroblastic tumor of mesentery—-Case report and review of imaging findings. Radiol Case Rep. (2021) 16:504–10. 10.1016/j.radcr.2020.12.027 - DOI - PMC - PubMed

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