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. 2023 Mar;11(3):501-507.
doi: 10.1111/andr.13352. Epub 2022 Dec 5.

The symptomatic burden of Peyronie's disease at presentation according to patient age: A critical analysis of the Peyronie's disease questionnaire (PDQ) domains

Simone Cilio  1   2 , Giuseppe Fallara  1   3 , Paolo Capogrosso  4 , Luigi Candela  1   3 , Federico Belladelli  1   3 , Edoardo Pozzi  1   3 , Christian Corsini  1   3 , Massimiliano Raffo  1   3 , Nicolò Schifano  1 , Luca Boeri  5 , Alessia d'Arma  1 , Ciro Imbimbo  2 , Vincenzo Mirone  2 , Francesco Montorsi  1   3 , Andrea Salonia  1   3
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Free article

The symptomatic burden of Peyronie's disease at presentation according to patient age: A critical analysis of the Peyronie's disease questionnaire (PDQ) domains

Simone Cilio et al. Andrology. 2023 Mar.
Free article

Abstract

Background: Peyronie's disease (PD) has a huge impact on patients' physical and psychological wellbeing.

Objectives: To investigate whether patients' age has an impact on PD symptomatic burden at first presentation.

Materials and methods: Data from 129 consecutive heterosexual patients seeking first medical attention for PD at a single andrological tertiary-referral centre were collected. All patients completed the International Index for Erectile Function (IIEF) and the PD questionnaire (PDQ). Descriptive statistics were used to compare clinical features between younger (≤40years) and older (>40 years) patients. Multivariable linear model assessed the impact of age, the degree of penile curvature and their impact on PDQ (total scores and its domains), after adjusting for PD duration and IIEF-erectile function domain scores.

Results: Of 129, 24 (18.6%) patients were ≤40 years old. Young patients presented with a less severe curvature than older patients (median [interquartile ranges] 20° [15-36] vs. 50° [40-80]; p = 0.04). However, younger age was associated with higher psychological and physical symptoms, PDQ-penile pain and PDQ-symptom bother scores (Coeff -0.11, -0.21 and -0.17, respectively) (all p < 0.05). Moreover, the greater the degree of curvature, the higher the PDQ-psychological and physical symptoms and the PDQ-symptom bother scores (Coeff. 0.21 and 0.22, respectively; all p < 0.05).

Conclusion: Around one in five men seeking first medical help for PD is younger than 40 years at presentation in the real-life setting. PD-related distress varies according to patients' age, with younger men presenting with a greater risk of penile pain and symptom bother despite lower curvature.

Keywords: PDQ; Peyronie's disease; age; epidemiology; young.

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References

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