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Multicenter Study
. 2023 Feb;46(2):371-378.
doi: 10.1016/j.rbmo.2022.11.001. Epub 2022 Nov 6.

Thrombocytopaenia and COVID-19 infection during pregnancy increases the risk of preeclampsia: a multicentre study

Marta Defez-Martin  1 , María Inmaculada Martín-Díaz  2 , Sandra Atienza-Ramirez  3 , Francisco Llorca-Colomer  4 , Maria Teresa Murillo-Llorente  4 , Marcelino Perez-Bermejo  5
Affiliations
Multicenter Study

Thrombocytopaenia and COVID-19 infection during pregnancy increases the risk of preeclampsia: a multicentre study

Marta Defez-Martin et al. Reprod Biomed Online. 2023 Feb.

Abstract

Research question: Is a low platelet count related to an increased risk of severe disease in pregnant women with active severe acute respiratory syndrome coronavirus 2 infection?

Design: A cross-sectional multicentre study in pregnant women with COVID-19 confirmed by polymerase chain reaction, antigen test, antibody test, or all.

Results: A total of 153 pregnant women with COVID-19 were included in the study, of whom 12.4% had thrombocytopaenia. Pregnant women with thrombocytopaenia were on average 3.1 years older (95% CI 0.18 to 6.38) than women without thrombocytopaenia. Pregnant smokers had a higher risk of thrombocytopaenia than non-smokers (OR 6.55, CI 95% 1.29 to 33.13). B Rh negative (B Rh-) pregnant women had a much higher risk of thrombocytopaenia than pregnant women with other blood groups (OR 16.83, CI 95% 1.42 to 199.8). Pregnant women with thrombocytopaenia had a much higher risk of suffering from preeclampsia (OR 16.2, CI 95% 1.35 to 193.4).

Conclusions: COVID-19 infection is not a risk factor for a low platelet count in pregnant women, although the risk is increased by smoking and in women with blood group B Rh-. In case of pregnancy with thrombocytopaenia, COVID-19 infection leads to an increased risk of preeclampsia.

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Figures

Figure 1
Figure 1
Box-and-whisker plot of platelet count in the three gestational trimesters. Paired student's t-test was used for comparisons between trimesters. *, statistical significance (P = 0.009).
Figure 2
Figure 2
Maternal blood group and mean platelet count in the infectious period. Analysis of variance test was used for comparisons between groups. *, statistical significance (P = 0.003).
See this image and copyright information in PMC

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