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. 2022 Nov 15;10(11):2936.
doi: 10.3390/biomedicines10112936.

The Lipid Profile and Biochemical Parameters of COPD Patients in Relation to Smoking Status

Cristina Vicol  1   2 , Ioana Buculei  1   2 , Oana Elena Melinte  2   3 , Mona Elisabeta Dobrin  4   5 , Emanuel Ioan Stavarache  2 , Cristina-Maria Gavrilescu  1 , Paraschiva Postolache  6 , Daniela Matei  1 , Antigona Trofor  3   4
Affiliations

The Lipid Profile and Biochemical Parameters of COPD Patients in Relation to Smoking Status

Cristina Vicol et al. Biomedicines. .

Abstract

Tobacco consumption is the most incriminated and studied risk factor for Chronic obstructive pulmonary disease (COPD), but other factors such as air pollution, are also linked to this disease. One of the known aspects of this chronic lung disease is that its occurrence is mainly due to the chronic inflammation of the airways. Lipid metabolism seems to be affected by smoking, with studies showing a correlation between this habit and high levels of triglycerides and low levels of high-density lipoprotein cholesterol (HDL-CHOL). Uric acid concentration is thought to reflect the antioxidative capacity of the body because it is the most abundant aqueous antioxidant. The aim of this study was to investigate the lipid profile and biochemical parameters of COPD patients in relation to smoking status. The present study was conducted between 2020 and 2021 in the Clinical Hospital of Pneumology in Iasi, Romania. Patients diagnosed with COPD (n = 52) were included and divided in three groups depending on their smoking status: non-smokers, smokers and ex-smokers. The obtained results show low correlations between COPD stages and serum uric acid concentrations (r = 0.4; p ˂ 0.05), smoking status (smoker/non-smoker/ex-smoker) and total serum cholesterol values (r = 0.45; p ˂ 0.05), but also between serum urea concentrations and the number of packs-years for the smoker/ex-smoker groups (r = 0.45, p ˂ 0.05). Smoking was associated with changes in the lipid profile of smokers and ex-smokers, along with increased low-density lipoprotein cholesterol (LDL-CHOL) and low serum uric acid values.

Keywords: COPD; biochemical parameters; lipid profile; smoking status; tobacco consumption; uric acid.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Q–Q plot for LDL-cholesterol (mg/dL) (a); HDL-cholesterol (mg/dL) (b); triglycerides (c) and total cholesterol (d).
Figure 1
Figure 1
Q–Q plot for LDL-cholesterol (mg/dL) (a); HDL-cholesterol (mg/dL) (b); triglycerides (c) and total cholesterol (d).
Figure 2
Figure 2
Linear regression between urea and PY (packs-years) (a); cholesterol and PY (packs-years) (b); uric acid and COPD stage (c).
Figure 2
Figure 2
Linear regression between urea and PY (packs-years) (a); cholesterol and PY (packs-years) (b); uric acid and COPD stage (c).
Figure 3
Figure 3
Linear regression between total lipids and triglycerides (a); triglycerides and HDL-CHOL (b); LDL-CHOL and total cholesterol (c) in patients with COPD.
Figure 4
Figure 4
Lipidic profile (triglycerides, total cholesterol, HDL-CHOL, LDL-CHOL) in blood serum of COPD patients depending on the smoking status (smokers/non-smokers/ex-smokers).
See this image and copyright information in PMC

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