Characteristics, Patterns of Care and Predictive Geriatric Factors in Elderly Patients Treated for High-Grade IDH-Mutant Gliomas: A French POLA Network Study

Coline Montégut¹, Jean-Sébastien Guillamo², François Ducray³, Caroline Dehais⁴, Elisabeth Cohen-Jonathan Moyal⁵, Christine Desenclos⁶, Antoine Petit⁷, Romuald Seizeur⁸, Lien Bekaert⁹, Claude Gaultier¹⁰, Marie Jeannette Motuo Fotso¹¹, Marie Blonski¹², Jean-Sébastien Frenel¹³, Elodie Vauléon¹⁴, Olivier Langlois¹⁵, Georges Noel¹⁶, Antoine F Carpentier¹⁷, Anna Luisa Di Stefano¹⁸, Charlotte Bronnimann¹⁹, Dominique Figarella-Branger^{20

21}, Olivier Chinot^{1

21}, Emeline Tabouret^{1

21}

Affiliations

¹ Neuro-Oncology Department, University Hospital La Timone, 264 Rue Saint Pierre, 13005 Marseille, France.
² Nîmes, Centre Hospitalier Universitaire de Nîmes Caremeau, Service de Neurologie, 30000 Nimes, France.
³ Neuro-Oncology Department, Hospices Civils de Lyon, Université Lyon 1, CRCL, UMR Inserm 1052_CNRS 5286, 69000 Lyon, France.
⁴ Service Neurology 2, Mazarin, Assistance Public-Hôpitaux de Paris, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Sorbonne University, 75013 Paris, France.
⁵ Département de Radiothérapie, Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse-Oncopole, 31059 Toulouse, France.
⁶ Neurosurgery Department, Hôpital Nord, Centre Hospitalo-Universitaire Amiens, 80000 Amiens, France.
⁷ Neurosurgery Department, Hôpital Jean Minjoz, Centre Hospitalo-Universitaire Besançon, 25000 Besançon, France.
⁸ Neurosurgery Department, Hôpital de la Cavale Blanche, Centre Hospitalo-Universitaire Brest, 29200 Brest, France.
⁹ Neurology Department, Centre Hospitalo-Universitaire de Caen, 14000 Caen, France.
¹⁰ Neurology Department, Centre Hospitalier Colmar, 68000 Colmar, France.
¹¹ Neurosurgery Department, Hôpital Nord, Centre Hospitalo-Universitaire Saint-Étienne, 42270 Saint-Priest en Jarez, France.
¹² Service de Neurologie, Hopital Central, Centre Hospitalier Régional Universitaire, 54000 Nancy, France.
¹³ Medical Oncology Department, Institut de Cancérologie de l'Ouest, 11 Boulevard Jacques Monod, 44800 Saint-Herblain, France.
¹⁴ Medical Oncology Department, Centre Eugene Marquis, INSERMU1242, University of Rennes, 35000 Rennes, France.
¹⁵ Neurosurgery Department, Centre Hospitalo-Universitaire Charles Nicolle, 76000 Rouen, France.
¹⁶ Radiotherapy Department, Centre Paul Strauss, 76000 Strasbourg, France.
¹⁷ Neurology Department, Hôpital Saint-Louis, 75010 Paris, France.
¹⁸ Service de Neurologie, Hôpital Foch, 92150 Suresnes, France.
¹⁹ Hôpital Saint-André Bordeaux, Centre Hospitalier Universitaire, Service d'Oncologie, 33000 Bordeaux, France.
²⁰ Service d'Anatomie Pathologique et de Neuropathologie, Centre Hospitalo-Universitaire Timone, APHM, 13005 Marseille, France.
²¹ GlioME Team, Institute of Neurophysiopathology, Aix-Marseille University 27 Bd Jean Moulin, 13005 Marseille, France.

PMID: 36428602
PMCID: PMC9688655
DOI: 10.3390/cancers14225509

Characteristics, Patterns of Care and Predictive Geriatric Factors in Elderly Patients Treated for High-Grade IDH-Mutant Gliomas: A French POLA Network Study

Coline Montégut et al. Cancers (Basel). 2022.

. 2022 Nov 9;14(22):5509.

doi: 10.3390/cancers14225509.

Authors

Affiliations

¹ Neuro-Oncology Department, University Hospital La Timone, 264 Rue Saint Pierre, 13005 Marseille, France.
² Nîmes, Centre Hospitalier Universitaire de Nîmes Caremeau, Service de Neurologie, 30000 Nimes, France.
³ Neuro-Oncology Department, Hospices Civils de Lyon, Université Lyon 1, CRCL, UMR Inserm 1052_CNRS 5286, 69000 Lyon, France.
⁴ Service Neurology 2, Mazarin, Assistance Public-Hôpitaux de Paris, Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Sorbonne University, 75013 Paris, France.
⁵ Département de Radiothérapie, Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse-Oncopole, 31059 Toulouse, France.
⁶ Neurosurgery Department, Hôpital Nord, Centre Hospitalo-Universitaire Amiens, 80000 Amiens, France.
⁷ Neurosurgery Department, Hôpital Jean Minjoz, Centre Hospitalo-Universitaire Besançon, 25000 Besançon, France.
⁸ Neurosurgery Department, Hôpital de la Cavale Blanche, Centre Hospitalo-Universitaire Brest, 29200 Brest, France.
⁹ Neurology Department, Centre Hospitalo-Universitaire de Caen, 14000 Caen, France.
¹⁰ Neurology Department, Centre Hospitalier Colmar, 68000 Colmar, France.
¹¹ Neurosurgery Department, Hôpital Nord, Centre Hospitalo-Universitaire Saint-Étienne, 42270 Saint-Priest en Jarez, France.
¹² Service de Neurologie, Hopital Central, Centre Hospitalier Régional Universitaire, 54000 Nancy, France.
¹³ Medical Oncology Department, Institut de Cancérologie de l'Ouest, 11 Boulevard Jacques Monod, 44800 Saint-Herblain, France.
¹⁴ Medical Oncology Department, Centre Eugene Marquis, INSERMU1242, University of Rennes, 35000 Rennes, France.
¹⁵ Neurosurgery Department, Centre Hospitalo-Universitaire Charles Nicolle, 76000 Rouen, France.
¹⁶ Radiotherapy Department, Centre Paul Strauss, 76000 Strasbourg, France.
¹⁷ Neurology Department, Hôpital Saint-Louis, 75010 Paris, France.
¹⁸ Service de Neurologie, Hôpital Foch, 92150 Suresnes, France.
¹⁹ Hôpital Saint-André Bordeaux, Centre Hospitalier Universitaire, Service d'Oncologie, 33000 Bordeaux, France.
²⁰ Service d'Anatomie Pathologique et de Neuropathologie, Centre Hospitalo-Universitaire Timone, APHM, 13005 Marseille, France.
²¹ GlioME Team, Institute of Neurophysiopathology, Aix-Marseille University 27 Bd Jean Moulin, 13005 Marseille, France.

PMID: 36428602
PMCID: PMC9688655
DOI: 10.3390/cancers14225509

Abstract

Background: Describe the characteristics, patterns of care, and predictive geriatric factors of elderly patients with IDHm high-grade glioma (HGG) included in the French POLA network. Material and Methods: The characteristics of elderly (≥70 years) patients IDHm HGG were compared to those of younger patients IDHm HGG (<70 years) and of elderly patients IDHwt HGG. Geriatric features were collected. Results: Out of 1433 HGG patients included, 119 (8.3%) were ≥70 years. Among them, 39 presented with IDHm HGG. The main characteristics of elderly IDHm HGG were different from those of elderly IDHwt HGG but similar to those of younger IDHm HGG. In contrast, their therapeutic management was different from those of younger IDHm HGG with less frequent gross total resection and radiotherapy. The median progression-free survival (PFS) and overall survival (OS) were longer for elderly patients IDHm HGG (29.3 months and 62.1 months) than elderly patients IDHwt HGG (8.3 months and 13.3 months) but shorter than those of younger patients IDHm HGG (69.1 months and not reached). Geriatric factors associated with PFS and OS were mobility, neuropsychological disorders, body mass index, and autonomy. Geriatric factors associated with PFS and OS were mobility, neuropsychological disorders, and body mass index, and autonomy. Conclusion: the outcome of IDHm HGG in elderly patients is better than that of IDHwt HGG. Geriatric assessment may be particularly important to optimally manage these patients.

Keywords: IDH mutation; elderly; geriatric assessment; high grade glioma.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Progression free-survival (A) and overall survival (B) according to the age (< or ≥70 years) and *IDH* mutation status. Progression free-survival (C) and overall survival (D) according to the age and the histological subtype of *IDH* mutated HGG patients.

**Figure 2**
Progression-free survival (A–D) according to geriatric parameters in elderly patients *IDHm* HGG: motricity (A), neuropsychological disorders (B), Body Mass Index (BMI) (C), and autonomy (D). Overall survival (E–H) according to geriatric parameters in elderly patients *IDHm* HGG: mobility (E), neuropsychological disorders (F), BMI (G), and autonomy (H).

**Figure 3**
(A). ROC (Receiver Operating Characteristics) curve of the Brain Geriatric Score according to long-term survivors. (B). Progression-Free Survival (left) and Overall Survival (right) of patients according to the BGS using a cut-off of 10. (C). Brain Tumor Geriatric Score detail.

See this image and copyright information in PMC

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Characteristics, Patterns of Care and Predictive Geriatric Factors in Elderly Patients Treated for High-Grade IDH-Mutant Gliomas: A French POLA Network Study

Affiliations

Characteristics, Patterns of Care and Predictive Geriatric Factors in Elderly Patients Treated for High-Grade IDH-Mutant Gliomas: A French POLA Network Study

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

LinkOut - more resources

Full Text Sources