Increased UV-inducibility of SOS functions in a dam-3 mutant of Escherichia coli K12 uvrA

Abstract

The dam-3 mutation caused a 2--4 fold increase in the susceptibility of E. coli K-12 uvrA to UV induction of prophage lambda, induced reactivation and mutagenesis of lambda, and mutation to histidine prototrophy. The increased inducibility exceeded the level expected by UV and dam-3 acting additively and independently, and suggests that the effects of UV and dam-3 interact in some way to potentiate induction of SOS functions.