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Review
. 2022 Nov 10;23(22):13877.
doi: 10.3390/ijms232213877.

The Association of Patent Ductus Arteriosus with Inflammation: A Narrative Review of the Role of Inflammatory Biomarkers and Treatment Strategy in Premature Infants

Yu-Jen Wei  1   2 , Rosie Hsu  3 , Yung-Chieh Lin  1 , Tak-Wah Wong  4   5   6 , Chung-Dann Kan  7 , Jieh-Neng Wang  1
Affiliations
Review

The Association of Patent Ductus Arteriosus with Inflammation: A Narrative Review of the Role of Inflammatory Biomarkers and Treatment Strategy in Premature Infants

Yu-Jen Wei et al. Int J Mol Sci. .

Abstract

Patent ductus arteriosus (PDA) is a common cardiovascular complication that complicates clinical care in the intensive care of premature infants. Prenatal and postnatal infections and the inflammation process can contribute to PDA, and intrauterine inflammation is a known risk factor of PDA. A variety of inflammatory biomarkers have been reported to be associated with PDA. Chorioamnionitis induces the fetal inflammatory process via several cytokines that have been reported to be associated with the presence of PDA and may have a role in the vascular remodeling process or vessel dilation of the ductus. On the other hand, anti-inflammatory agents, such as antenatal steroids, decrease PDA incidence and severity in patients born to those with chorioamnionitis. Proinflammatory cytokines, which are expressed more significantly in preterm neonates and chorioamnionitis, are associated with the presence of PDA. In this review, we focus on the pathogenesis of PDA in preterm infants and the role of biomarkers associated with the perinatal inflammatory process.

Keywords: chorioamnionitis; ductus arteriosus; intrauterine inflammation; preterm infants.

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Conflict of interest statement

There are no conflict of interest.

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